Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.32 |
| ▸ | STAT6 | P42226 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20260920 | 0.90 | GAA (0.41) | MAPK8MAPK10MAPK9PIK3CDPIK3C2B | |
| SCHEMBL18278851 | 0.88 | MAPK8 (0.34) | MAPK8MAPK10ACVR1MAPK9TTK | |
| SCHEMBL20260918 | 0.86 | CSNK2A2 (0.36) | MAPK8MAPK10 | |
| SCHEMBL18278868 | 0.85 | MAPK8 (0.34) | MAPK8MAPK10ACVR1MAPK9SOS1 | |
| SCHEMBL20260395 | 0.84 | P2RX7 (0.39) | MAPK8MAPK10ACVR1MAPK9TTK | |
| SCHEMBL18278673 | 0.84 | MAPK8 (0.36) | MAPK8MAPK10ACVR1MAPK9TTK | |
| SCHEMBL20260359 | 0.84 | TTK (0.44) | MAPK8MAPK10ACVR1MAPK9TTK | |
| SCHEMBL20242665 | 0.83 | MAPK10 (0.37) | MAPK8MAPK10ACVR1MAPK9STAT6 | |
| SCHEMBL20260873 | 0.83 | MAPT (0.42) | MAPK8MAPK10MAPK9POLBSTAT6 | |
| SCHEMBL20260795 | 0.83 | MAPK10 (0.41) | MAPK8MAPK10ACVR1MAPK9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018106646-A1 | AMINOTRIAZOLES FOR THE TREATMENT OF DEMYELINATING DISEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-06-14 | — | — | WO | disclosed |