Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.73 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.62 |
| ▸ | MAOB | P27338 | 4/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.60 |
| ▸ | BRD2 | P25440 | 4/20 | 0.58 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.58 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26079993 | 0.85 | ABCB1 (0.80) | BRD4ABCB1BRD2BRD3BRDT | |
| SCHEMBL20271941 | 0.84 | BRD4 (1.00) | BRD4ABCB1MAOBMAOABRD2 | |
| SCHEMBL17193738 | 0.84 | MAOB (0.82) | ABCB1MAOBMAOAMEN1KMT2A | |
| SCHEMBL30599697 | 0.84 | BRD4 (1.00) | BRD4ABCB1MAOBMAOABRD2 | |
| SCHEMBL20271549 | 0.82 | BRD4 (0.72) | BRD4ABCB1MAOBMAOABRD2 | |
| SCHEMBL20271547 | 0.82 | BRD4 (0.72) | BRD4ABCB1MAOBMAOABRD2 | |
| SCHEMBL26080234 | 0.81 | BRD4 (0.77) | BRD4ABCB1MAOBMAOABRD2 | |
| SCHEMBL26080231 | 0.81 | BRD4 (0.77) | BRD4ABCB1MAOBMAOABRD2 | |
| SCHEMBL20271922 | 0.79 | BRD4 (0.71) | BRD4ABCB1MAOBMAOABRD2 | |
| SCHEMBL20291210 | 0.79 | BRD4 (0.67) | BRD4ABCB1MAOBMAOABRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3554503-B1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | UNIV TEXAS (US) | 2023-10-04 | — | — | EP | disclosed |
| EP-3554503-B1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | UNIV TEXAS (US) | 2023-10-04 | — | — | EP | disclosed |
| US-11117865-B2 | Inhibitors of bromodomain-containing protein 4 (BRD4) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-09-14 | — | — | US | disclosed |
| US-11117865-B2 | Inhibitors of bromodomain-containing protein 4 (BRD4) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-09-14 | — | — | US | disclosed |
| EP-3554503-A1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | Zhou, Jia (US) | 2019-10-23 | — | — | EP | disclosed |
| WO-2018112037-A1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | ZHOU JIA (US) | 2018-06-21 | — | — | WO | disclosed |
| WO-2018112037-A1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | ZHOU JIA (US) | 2018-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11117865-B2 | Inhibitors of bromodomain-containing protein 4 (BRD4) | BRD4, NFKBIA, NFRKB | BRD4 1/4885ABCB1 2949/4885MAOB 4035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.