Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.67 |
| ▸ | BRD2 | P25440 | 4/20 | 0.61 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.61 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 6/20 | 0.47 |
| ▸ | MAOA | P21397 | 5/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20291074 | 0.89 | BRD4 (0.71) | BRD4BRD2BRD3BRDTABCB1 | |
| SCHEMBL26080231 | 0.83 | BRD4 (0.77) | BRD4BRD2BRD3BRDTABCB1 | |
| SCHEMBL26079993 | 0.81 | ABCB1 (0.80) | BRD4BRD2BRD3BRDTABCB1 | |
| SCHEMBL20271941 | 0.80 | BRD4 (1.00) | BRD4BRD2BRD3BRDTABCB1 | |
| SCHEMBL30599697 | 0.80 | BRD4 (1.00) | BRD4BRD2BRD3BRDTABCB1 | |
| SCHEMBL20291079 | 0.80 | BRD4 (0.71) | BRD4BRD2BRD3BRDTABCB1 | |
| SCHEMBL20270787 | 0.79 | BRD4 (0.73) | BRD4BRD2BRD3BRDTABCB1 | |
| SCHEMBL20271547 | 0.78 | BRD4 (0.72) | BRD4BRD2BRD3BRDTABCB1 | |
| SCHEMBL20271549 | 0.78 | BRD4 (0.72) | BRD4BRD2BRD3BRDTABCB1 | |
| SCHEMBL26080234 | 0.77 | BRD4 (0.77) | BRD4BRD2BRD3BRDTABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018112037-A1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | ZHOU JIA (US) | 2018-06-21 | — | — | WO | disclosed |