SCHEMBL20274258

SCHEMBL20274258

COC(=O)c1ccc(C(=O)C(=O)c2ccc(Oc3ccc(C(=O)C(=O)c4ccc(C=O)cc4)cc3)cc2)cc1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.74
PARP10 Q53GL7 1/20 0.58
PARP3 Q9Y6F1 1/20 0.58
CA1 P00915 3/20 0.53
CA2 P00918 3/20 0.53
MAPT P10636 5/20 0.50
NPC1 O15118 2/20 0.50
LMNA P02545 1/20 0.50
CYP2A6 P11509 1/20 0.47
CES2 O00748 1/20 0.47
CES1 P23141 1/20 0.47
TDP1 Q9NUW8 1/20 0.46
CA12 O43570 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
PTPN1 P18031 1/20 0.45
STS P08842 1/20 0.45
RAB9A P51151 2/20 0.45
KDM4E B2RXH2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4598157 0.95 ALDH1A1 (0.82) ALDH1A1PARP10PARP3CA1CA2
SCHEMBL20252722 0.88 CA1 (0.67) ALDH1A1PARP10CA1CA2MAPT
SCHEMBL20274257 0.86 ALDH1A1 (0.68) ALDH1A1PARP10PARP3CA1CA2
SCHEMBL79533 0.86 ALDH1A1 (1.00) ALDH1A1CA1CA2MAPTNPC1
SCHEMBL15373867 0.83 ALDH1A1 (0.79) ALDH1A1PARP10PARP3CA1CA2
SCHEMBL69218 0.82 CA1 (0.75) ALDH1A1PARP10CA1CA2MAPT
SCHEMBL14789231 0.81 ALDH1A1 (0.89) ALDH1A1CA1CA2MAPTNPC1
SCHEMBL2389679 0.81 ALDH1A1 (0.89) ALDH1A1CA1CA2MAPTNPC1
SCHEMBL210094 0.81 MAPT (0.77) ALDH1A1CA1CA2MAPTNPC1
SCHEMBL16880883 0.80 ALDH1A1 (0.58) ALDH1A1PARP10PARP3MAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3336126-A1 POLYARYLENE RESINS Rohm and Haas Electronic Materials LLC (US) 2018-06-20 EP disclosed