SCHEMBL4598157

SCHEMBL4598157

COC(=O)c1ccc(Oc2ccc(C=O)cc2)cc1

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.82
PARP10 Q53GL7 1/20 0.64
PARP3 Q9Y6F1 1/20 0.64
CA1 P00915 2/20 0.58
CA2 P00918 2/20 0.58
MAPT P10636 6/20 0.54
NPC1 O15118 2/20 0.54
LMNA P02545 1/20 0.54
CYP2A6 P11509 1/20 0.52
TDP1 Q9NUW8 1/20 0.50
CA12 O43570 1/20 0.50
CA7 P43166 1/20 0.50
CA9 Q16790 1/20 0.50
CA14 Q9ULX7 1/20 0.50
PTPN1 P18031 1/20 0.49
STS P08842 1/20 0.49
RAB9A P51151 3/20 0.48
KDM4E B2RXH2 1/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20274258 0.95 ALDH1A1 (0.74) ALDH1A1PARP10PARP3CA1CA2
SCHEMBL20274257 0.91 ALDH1A1 (0.68) ALDH1A1PARP10PARP3CA1CA2
SCHEMBL28033399 0.91 ALDH1A1 (1.00) ALDH1A1CA1CA2MAPTNPC1
SCHEMBL79533 0.91 ALDH1A1 (1.00) ALDH1A1CA1CA2MAPTNPC1
SCHEMBL15373867 0.88 ALDH1A1 (0.79) ALDH1A1PARP10PARP3CA1CA2
SCHEMBL69218 0.87 CA1 (0.75) ALDH1A1PARP10CA1CA2MAPT
SCHEMBL14789231 0.85 ALDH1A1 (0.89) ALDH1A1CA1CA2MAPTNPC1
SCHEMBL2389679 0.85 ALDH1A1 (0.89) ALDH1A1CA1CA2MAPTNPC1
SCHEMBL210094 0.85 MAPT (0.77) ALDH1A1CA1CA2MAPTNPC1
SCHEMBL20772350 0.84 ALDH1A1 (0.58) ALDH1A1PARP10PARP3CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250346585-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2025-11-13 US disclosed
US-12312316-B2 Compounds and methods for the targeted degradation of androgen receptor ARVINAS OPERATIONS, INC. (US) 2025-05-27 US disclosed
US-20240059686-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF THE ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. (US) 2024-02-22 US disclosed
WO-2023183405-A2 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2023-09-28 WO disclosed
WO-2023183405-A2 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2023-09-28 WO disclosed
US-11427548-B2 Compounds and methods for the targeted degradation of androgen receptor ARVINAS OPERATIONS, INC. (US) 2022-08-30 US disclosed
US-11352351-B2 Compounds and methods for the targeted degradation of androgen receptor ARVINAS OPERATIONS, INC. (US) 2022-06-07 US disclosed
US-11352351-B2 Compounds and methods for the targeted degradation of androgen receptor ARVINAS OPERATIONS, INC. (US) 2022-06-07 US disclosed
EP-3658548-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR Arvinas Operations, Inc. (US) 2020-06-03 EP disclosed
CN-111212835-A Compounds and methods for targeted degradation of androgen receptors 阿尔维纳斯运营股份有限公司 2020-05-29 CN disclosed
US-20170327469-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2017-11-16 US disclosed
US-20160214972-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2016-07-28 US disclosed
WO-2016118666-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF THE ANDROGEN RECEPTOR Arvinas, Inc. (US) 2016-07-28 WO disclosed
US-20160214972-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2016-07-28 US disclosed
US-20160214972-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2016-07-28 US disclosed
WO-2016118666-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF THE ANDROGEN RECEPTOR Arvinas, Inc. (US) 2016-07-28 WO disclosed
EP-1924265-A2 CHEMOKINE RECEPTOR BINDING COMPOUNDS Genzyme Corporation (US) 2008-05-28 EP disclosed
US-20070066624-A1 Chemokine receptor binding compounds ANORMED, INC. (CA) 2007-03-22 US disclosed
WO-2007022371-A2 CHEMOKINE RECEPTOR BINDING COMPOUNDS GENZYME CORPORATION (US) 2007-02-22 WO disclosed
US-4749773-A Condensation polymers containing methine ultraviolet radiation-absorbing residues and shaped articles produced therefrom EASTMAN KODAK COMPANY (US) 1988-06-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160214972-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AR, ESRRA, MDM2 ALDH1A1 460/4885PARP10 845/4885PARP3 392/4885
US-20170327469-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AR, MDM2, ESRRA ALDH1A1 514/4885PARP10 1012/4885PARP3 400/4885
US-12312316-B2 Compounds and methods for the targeted degradation of androgen receptor AR, MDM2, ESRRA ALDH1A1 514/4885PARP10 1012/4885PARP3 400/4885
US-20240059686-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF THE ANDROGEN RECEPTOR AR, VHL, MDM2 ALDH1A1 520/4885PARP10 909/4885PARP3 405/4885
US-20250346585-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS C5, C1S, C9 ALDH1A1 1707/4885PARP10 426/4885PARP3 465/4885
US-11352351-B2 Compounds and methods for the targeted degradation of androgen receptor AR, ESRRA, MDM2 ALDH1A1 460/4885PARP10 845/4885PARP3 392/4885
US-20070066624-A1 Chemokine receptor binding compounds CCR5, CCR4, CCR1 ALDH1A1 3484/4885PARP10 2390/4885PARP3 2189/4885
US-11427548-B2 Compounds and methods for the targeted degradation of androgen receptor AR, MDM2, ESRRA ALDH1A1 514/4885PARP10 1012/4885PARP3 400/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.