Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 13/20 | 0.61 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL309189 | 0.78 | TPH1 (1.00) | TPH1 | |
| SCHEMBL309188 | 0.78 | TPH1 (1.00) | TPH1 | |
| SCHEMBL320652 | 0.78 | TPH1 (1.00) | TPH1 | |
| SCHEMBL3412957 | 0.77 | TPH1 (0.61) | TPH1 | |
| SCHEMBL5325695 | 0.68 | GRIA1 (0.39) | TPH1TYRDOHHKDM4EGRIA1 | |
| SCHEMBL20274801 | 0.65 | TPH1 (0.70) | TPH1 | |
| Serine SCHEMBL17959435 | 0.64 | CYP1A2 (0.45) | TPH1GRIA1GRIA2GRIA4GRIK5 | |
| SCHEMBL2262820 | 0.63 | KMO (0.40) | TPH1TYRDOHHKDM4EKMO | |
| SCHEMBL2262827 | 0.63 | KMO (0.40) | TPH1TYRDOHHKDM4EKMO | |
| Benzoguanamine SCHEMBL21351508 | 0.63 | TPH1 (0.71) | TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2386547-B1 | Multicyclic amino acid derivatives and methods of their use | LEXICON PHARMACEUTICALS INC (US) | 2018-06-20 | — | — | EP | disclosed |