Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 12/20 | 0.61 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL308330 | 0.88 | TPH1 (0.66) | TPH1CTSSCTSKCTSBPTPN1 | |
| SCHEMBL308331 | 0.88 | TPH1 (0.66) | TPH1CTSSCTSKCTSBPTPN1 | |
| SCHEMBL31584190 | 0.80 | CTSS (0.61) | CTSSCTSKCTSBATMPTPN1 | |
| SCHEMBL7353984 | 0.80 | CTSS (0.61) | CTSSCTSKCTSBATMPTPN1 | |
| SCHEMBL9266214 | 0.78 | CTSB (0.52) | CTSSCTSKCTSBATMPTPN1 | |
| SCHEMBL15315375 | 0.78 | TPH1 (0.68) | TPH1 | |
| SCHEMBL308167 | 0.76 | TPH1 (1.00) | TPH1 | |
| SCHEMBL1531589 | 0.74 | CTSS (0.62) | CTSSCTSKCTSBATMPTPN1 | |
| SCHEMBL1531592 | 0.74 | CTSS (0.62) | CTSSCTSKCTSBATMPTPN1 | |
| SCHEMBL15521493 | 0.74 | CTSS (0.62) | CTSSCTSKCTSBATMPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2386547-B1 | Multicyclic amino acid derivatives and methods of their use | LEXICON PHARMACEUTICALS INC (US) | 2018-06-20 | — | — | EP | disclosed |