Sugi Predict

Sugi Predict / Compounds / SCHEMBL202789

SCHEMBL202789

SCHEMBL202789

BrCc1coc(-c2ccccc2)n1

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ DRD2 P14416 4/20 0.54
▸ DRD4 P21917 3/20 0.54
▸ DRD3 P35462 3/20 0.54
▸ ALDH1A1 P00352 1/20 0.46
▸ FFAR1 O14842 1/20 0.45
▸ LMNA P02545 1/20 0.44
▸ HDAC1 Q13547 2/20 0.44
▸ HDAC8 Q9BY41 2/20 0.44
▸ HDAC6 Q9UBN7 2/20 0.44
▸ GAA P10253 1/20 0.42
▸ TSHR P16473 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ ENPP3 O14638 2/20 0.41
▸ ENPP1 P22413 2/20 0.41
▸ HTR2A P28223 1/20 0.40
▸ HRH1 P35367 1/20 0.40
▸ PPARG P37231 3/20 0.40
▸ PPARA Q07869 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26315182 0.81 HDAC1 (0.46) HDAC1HDAC8HDAC6ENPP3ENPP1
SCHEMBL3126496 0.81 DRD2 (0.54) DRD2DRD4DRD3ALDH1A1FFAR1
SCHEMBL1436020 0.81 DRD2 (0.58) DRD2DRD4DRD3ALDH1A1FFAR1
SCHEMBL4826786 0.81 DRD2 (0.54) DRD2DRD4DRD3ALDH1A1FFAR1
SCHEMBL12432902 0.81 DRD2 (0.54) DRD2DRD4DRD3ALDH1A1FFAR1
SCHEMBL6593764 0.81 DRD2 (0.54) DRD2DRD4DRD3ALDH1A1FFAR1
SCHEMBL5544565 0.81 DRD2 (0.54) DRD2DRD4DRD3ALDH1A1FFAR1
SCHEMBL4034904 0.81 DRD2 (0.54) DRD2DRD4DRD3ALDH1A1FFAR1
Hydrochloric Acid SCHEMBL21879627 0.79 DRD2 (0.53) DRD2DRD4DRD3ALDH1A1FFAR1
SCHEMBL5106193 0.78 DRD2 (0.51) DRD2DRD4DRD3ALDH1A1FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250179008-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. (US) 2025-06-05 — — US disclosed
US-9983218-B2 Indole and indoline derivatives and methods of use thereof ABBVIE INC. (US) 2018-05-29 — — US disclosed
US-20180024144-A1 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF ABBVIE INC. (US) 2018-01-25 — — US disclosed
US-9625475-B2 Indole and indoline derivatives and methods of use thereof ABBVIE INC. (US) 2017-04-18 — — US disclosed
US-20150353550-A1 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF ABBVIE INC (US) 2015-12-10 — — US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 — — US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 — — US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 — — US disclosed
US-9063126-B2 Indole and indoline derivatives and methods of use thereof ABBVIE INC. (US) 2015-06-23 — — US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 — — US disclosed
US-8088791-B2 Antibacterial agents Biots Scientific Management Pty Ltd (AU) 2012-01-03 — — US disclosed
US-8088791-B2 Antibacterial agents Biots Scientific Management Pty Ltd (AU) 2012-01-03 — — US disclosed
EP-2344505-A2 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF Abbott Laboratories (US) 2011-07-20 — — EP disclosed
WO-2011008312-A2 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF ABBOTT LABORATORIES (US) 2011-01-20 — — WO disclosed
US-20100249105-A1 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF ABBOTT LABORATORIES (US) 2010-09-30 — — US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 — — US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 — — US disclosed
US-20100087471-A1 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF ABBOTT LABORATORIES (US) 2010-04-08 — — US disclosed
WO-2010036998-A2 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF ABBOTT LABORATORIES (US) 2010-04-01 — — WO disclosed
WO-2007107758-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2007-09-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100249105-A1 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF IDO1, IDO2, TPH1 DRD2 46/4885DRD4 56/4885DRD3 55/4885
US-20150191420-A1 ANTIBACTERIAL AGENTS ALK, ARG1, ROS1 DRD2 540/4885DRD4 894/4885DRD3 867/4885
US-20180024144-A1 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF IDO1, IDO2, TPH1 DRD2 46/4885DRD4 56/4885DRD3 55/4885
US-20250179008-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 DRD2 526/4885DRD4 786/4885DRD3 475/4885
US-20100087471-A1 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF IDO1, IDO2, TPH1 DRD2 46/4885DRD4 56/4885DRD3 55/4885
US-20100173933-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 DRD2 526/4885DRD4 786/4885DRD3 475/4885
US-20150353550-A1 INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF IDO1, IDO2, TPH1 DRD2 46/4885DRD4 56/4885DRD3 55/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.