Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 8/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21783706 | 1.00 | RORC (0.47) | RORCNAMPTPKMSLC6A2SLC6A4 | |
| SCHEMBL20282922 | 0.91 | RORC (0.49) | RORCNAMPTPKMCA1CA2 | |
| SCHEMBL21783621 | 0.91 | RORC (0.49) | RORCNAMPTPKMCA1CA2 | |
| SCHEMBL20282907 | 0.90 | RORC (0.56) | RORCNAMPTPKMCA1CA2 | |
| SCHEMBL23021429 | 0.84 | RORC (0.48) | RORCSLC6A2SLC6A4SLC6A3TACR1 | |
| SCHEMBL23021587 | 0.84 | RORC (0.48) | RORCSLC6A2SLC6A4SLC6A3TACR1 | |
| SCHEMBL21783697 | 0.79 | RORC (0.51) | RORCNAMPTNR1I2TACR1 | |
| SCHEMBL20283006 | 0.79 | RORC (0.51) | RORCNR1I2TACR1 | |
| SCHEMBL20282938 | 0.78 | RORC (0.46) | RORCNAMPTCA1CA2CA9 | |
| SCHEMBL20283160 | 0.78 | RORC (0.45) | RORCNAMPTCA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10954215-B2 | Compounds as modulators of ROR gamma | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-03-23 | — | — | US | disclosed |
| US-20200071298-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-03-05 | — | — | US | disclosed |
| WO-2018111803-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10954215-B2 | Compounds as modulators of ROR gamma | RORB, RORC, RORA | RORC 2/4885NAMPT 1562/4885PKM 2613/4885 |
| US-20200071298-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | RORC, RORB, RORA | RORC 1/4885NAMPT 1203/4885PKM 2628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.