Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.45 |
| ▸ | OTC | P00480 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 7/20 | 0.40 |
| ▸ | NOS1 | P29475 | 5/20 | 0.40 |
| ▸ | NOS3 | P29474 | 4/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.39 |
| ▸ | ARG2 | P78540 | 4/20 | 0.38 |
| ▸ | ARG1 | P05089 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL4203993 | 0.96 | OTC (0.46) | GSROTCNOS2NOS1NOS3 | |
| Arginine SCHEMBL28160285 | 0.96 | OTC (0.46) | GSROTCNOS2NOS1NOS3 | |
| Arginine SCHEMBL4208039 | 0.96 | OTC (0.46) | GSROTCNOS2NOS1NOS3 | |
| Arginine SCHEMBL27889814 | 0.96 | OTC (0.46) | GSROTCNOS2NOS1NOS3 | |
| Arginine SCHEMBL17550 | 0.96 | OTC (0.46) | GSROTCNOS2NOS1NOS3 | |
| Arginine SCHEMBL5965923 | 0.96 | OTC (0.46) | GSROTCNOS2NOS1NOS3 | |
| Arginine SCHEMBL936448 | 0.96 | OTC (0.46) | GSROTCNOS2NOS1NOS3 | |
| Arginine SCHEMBL26623152 | 0.92 | OTC (0.43) | GSROTCNOS2NOS1NOS3 | |
| Arginine SCHEMBL150228 | 0.91 | OTC (0.49) | GSROTCNOS2NOS1NOS3 | |
| Arginine SCHEMBL27692295 | 0.91 | OTC (0.49) | GSROTCNOS2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778888-B2 | Cystine knot peptides binding to alpha IIb beta 3 integrins and methods of use | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-07-15 | — | — | US | disclosed |
| US-20110136740-A1 | CYSTINE KNOT PEPTIDES BINDING TO ALPHA IIb BETA 3 INTEGRINS AND METHODS OF USE | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-06-09 | — | — | US | disclosed |