Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.46 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.43 |
| ▸ | GSR | P00390 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 6/20 | 0.41 |
| ▸ | NOS3 | P29474 | 5/20 | 0.41 |
| ▸ | NOS1 | P29475 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | GRM8 | O00222 | 1/20 | 0.37 |
| ▸ | GRM6 | O15303 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL4203993 | 1.00 | OTC (0.46) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL27889814 | 1.00 | OTC (0.46) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL4208039 | 1.00 | OTC (0.46) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL17550 | 1.00 | OTC (0.46) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL28160285 | 1.00 | OTC (0.46) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL5965923 | 1.00 | OTC (0.46) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL26623152 | 0.96 | OTC (0.43) | OTCDDAH1GSRNOS2NOS3 | |
| Aspartic Acid SCHEMBL2028617 | 0.96 | GSR (0.45) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL150228 | 0.95 | OTC (0.49) | OTCDDAH1GSRNOS2NOS3 | |
| Arginine SCHEMBL27692295 | 0.95 | OTC (0.49) | OTCDDAH1GSRNOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103989624-B | A kind of irinotecan hydrochloride composition and preparation method thereof | 中国科学院上海药物研究所 | 2018-04-27 | — | — | CN | claimed |
| CN-107669632-A | A kind of pharmaceutical carrier, micella, antitumor and antitumor cell diversion medicaments preparation, and its production and use | 四川大学 | 2018-02-09 | — | — | CN | claimed |
| CN-106749517-A | A kind of polysaccharide derivates containing polypeptide targeting factor and preparation method thereof | 中山大学 | 2017-05-31 | — | — | CN | claimed |
| CN-105866206-A | Method for in-situ and real-time detection of concentration of hydrogen peroxide in living cells | 国家纳米科学中心 | 2016-08-17 | — | — | CN | claimed |
| CN-104784708-A | NGR (asparagine-glycine-arginine)-PEG (polyethylene glycol)-QD (quantum dot) nano material and preparation method thereof | CHENG YUAN | 2015-07-22 | — | — | CN | claimed |
| CN-103212092-B | Multifunctional coordination copolymer nanometer material as well preparation method and application thereof | UNIV SHANGHAI | 2014-09-17 | — | — | CN | claimed |
| CN-103989624-A | Irinotecan hydrochloride composition and preparation method thereof | SHANGHAI INST MATERIA MEDICA | 2014-08-20 | — | — | CN | claimed |
| EP-2296580-A2 | CORNEAL ONLAY DEVICES AND METHODS | Forsight Labs, Llc (US) | 2011-03-23 | — | — | EP | claimed |
| EP-2276420-A2 | THERAPEUTIC DEVICE FOR PAIN MANAGEMENT AND VISION | Forsight Labs, Llc (US) | 2011-01-26 | — | — | EP | claimed |
| WO-2009145842-A9 | THERAPEUTIC DEVICE FOR PAIN MANAGEMENT AND VISION | FORSIGHT LABS, LLC (US) | 2010-11-18 | — | — | WO | claimed |
| WO-2009146151-A2 | CORNEAL ONLAY DEVICES AND METHODS | FORSIGHT LABS, LLC (US) | 2009-12-03 | — | — | WO | claimed |
| WO-2009145842-A2 | THERAPEUTIC DEVICE FOR PAIN MANAGEMENT AND VISION | FORSIGHT LABS, LLC (US) | 2009-12-03 | — | — | WO | claimed |
| US-7470424-B2 | Cultured cell construct containing spheroids of cultured animal cells and utilization thereof | TRANSPARENT INC. (JP) | 2008-12-30 | — | — | US | claimed |
| CN-101314641-A | Aliphatic polyester series microspheres, preparation and application thereof | CHINESE ACAD INST CHEMISTRY (CN) | 2008-12-03 | — | — | CN | claimed |
| WO-2007146319-A9 | METHODS AND APPARATUS FOR USING POLYMER-BASED BEADS AND HYDROGELS FOR CARDIAC APPLICATIONS | SYMPHONY MEDICAL INC (US) | 2008-04-24 | — | — | WO | claimed |
| WO-2007146319-A2 | METHODS AND APPARATUS FOR USING POLYMER-BASED BEADS AND HYDROGELS FOR CARDIAC APPLICATIONS | SYMPHONY MEDICAL, INC. (US) | 2007-12-21 | — | — | WO | claimed |
| CN-1328289-C | Endothelium chalone capable of improving antitumor activity with changed structure and its use | UNIV HARBIN MEDICAL (CN) | 2007-07-25 | — | — | CN | claimed |
| CN-1670035-A | Endothelium chalone capable of improving antitumor activity with changed structure and its use | UNIV HARBIN MEDICAL (CN) | 2005-09-21 | — | — | CN | claimed |
| US-20250345273-A1 | DEGRADABLE POLY(VINYL ALCOHOL) HYDROGELS FOR WOUND HEALING APPLICATIONS | OFFICE OF TECHNOLOGY TRANSFER (US) | 2025-11-13 | — | — | US | disclosed |
| US-5415636-A | Dilation-drug delivery catheter | SCHNEIDER (USA) INC (US) | 1995-05-16 | — | — | US | disclosed |