SCHEMBL2028870

SCHEMBL2028870

[CH2]c1cccc([Sn](C)(C)C)c1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15267169 0.81 ACHE (0.35)
SCHEMBL9462073 0.72 ACHE (0.55)
SCHEMBL4039180 0.72 ALDH1A1 (0.44)
SCHEMBL150818 0.71
SCHEMBL4036086 0.70 ACHE (0.48)
SCHEMBL3051672 0.70 CYP3A4 (0.52)
SCHEMBL5951672 0.70 TP53 (0.54)
SCHEMBL5952322 0.68 MAOA (0.44)
SCHEMBL4035400 0.67 ACHE (0.52)
SCHEMBL352235 0.66 TSHR (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2331542-B1 A3 ADENOSINE RECEPTOR ANTAGONISTS AND PARTIAL AGONISTS US HEALTH (US) 2016-07-27 EP disclosed
US-9181253-B2 Adenosine receptor agonists, partial agonists, and antagonists THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2015-11-10 US disclosed
US-8916570-B2 A3 adenosine receptor agonists and antagonists THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2014-12-23 US disclosed
US-8796291-B2 A3 adenosine receptor antagonists and partial agonists THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2014-08-05 US disclosed
US-20120252823-A1 ADENOSINE RECEPTOR AGONISTS, PARTIAL AGONISTS, AND ANTAGONISTS SERVICES (US) 2012-10-04 US disclosed
US-20120184569-A1 A3 ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) 2012-07-19 US disclosed
US-20110171130-A1 A3 ADENOSINE RECEPTOR ANTAGONISTS AND PARTIAL AGONISTS The United States of America, as represented by the Secretary ,Deptment of Health and HumanService (US) 2011-07-14 US disclosed
EP-2331542-A2 A3 ADENOSINE RECEPTOR ANTAGONISTS AND PARTIAL AGONISTS The United States of America, as Represented by The Secretary, Department of Health and Human Services (US) 2011-06-15 EP disclosed
WO-2010014921-A2 A3 ADENOSINE RECEPTOR ANTAGONISTS AND PARTIAL AGONISTS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2010-02-04 WO disclosed