Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 9/20 | 0.72 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PKLR | P30613 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20291379 | 0.85 | HDAC3 (0.57) | KIF11HDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL23806098 | 0.84 | KDR (0.64) | KIF11TRPV1HDAC1HDAC8HDAC6 | |
| SCHEMBL20291376 | 0.84 | HDAC3 (0.56) | KIF11HDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL20291405 | 0.84 | PKM (0.58) | KIF11EPHX2TRPV1HDAC3HDAC4 | |
| SCHEMBL16208488 | 0.84 | KIF11 (1.00) | KIF11CRBNPKMPKLR | |
| SCHEMBL20291247 | 0.82 | HDAC1 (0.57) | KIF11HDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL24508435 | 0.80 | APOB (0.60) | KIF11MAP4K1 | |
| SCHEMBL16208485 | 0.79 | KIF11 (0.85) | KIF11CRBNPKMPKLR | |
| SCHEMBL2238253 | 0.79 | KIF11 (0.77) | KIF11PKMPKLR | |
| SCHEMBL20291249 | 0.79 | HDAC3 (0.53) | KIF11HDAC3HDAC4HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3554503-B1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | UNIV TEXAS (US) | 2023-10-04 | — | — | EP | disclosed |
| EP-3554503-B1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | UNIV TEXAS (US) | 2023-10-04 | — | — | EP | disclosed |
| US-11117865-B2 | Inhibitors of bromodomain-containing protein 4 (BRD4) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-09-14 | — | — | US | disclosed |
| US-11117865-B2 | Inhibitors of bromodomain-containing protein 4 (BRD4) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-09-14 | — | — | US | disclosed |
| WO-2018112037-A1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | ZHOU JIA (US) | 2018-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11117865-B2 | Inhibitors of bromodomain-containing protein 4 (BRD4) | BRD4, NFKBIA, NFRKB | KIF11 2556/4885EPHX2 4369/4885TRPV1 2463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.