Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2029904 | 1.00 | TSHR (0.56) | TSHRHTTALDH1A1LMNASTAT3 | |
| SCHEMBL8844963 | 0.80 | TSHR (0.60) | TSHRHTTALDH1A1LMNASTAT3 | |
| SCHEMBL8940495 | 0.80 | TSHR (0.60) | TSHRHTTALDH1A1LMNASTAT3 | |
| SCHEMBL14830221 | 0.80 | TSHR (0.60) | TSHRHTTALDH1A1LMNASTAT3 | |
| SCHEMBL14830246 | 0.80 | TSHR (0.60) | TSHRHTTALDH1A1LMNASTAT3 | |
| SCHEMBL8940504 | 0.79 | TSHR (0.58) | TSHRHTTALDH1A1LMNASTAT3 | |
| SCHEMBL8940508 | 0.79 | TSHR (0.58) | TSHRHTTALDH1A1LMNASTAT3 | |
| SCHEMBL509011 | 0.77 | CA1 (0.57) | TSHRHTTALDH1A1TP53MEN1 | |
| SCHEMBL13576478 | 0.74 | TSHR (0.77) | TSHRHTTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL29475007 | 0.73 | CA2 (0.68) | ALDH1A1STAT3KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150166594-A1 | MOENOMYCIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-06-18 | — | — | US | disclosed |
| US-8604004-B2 | Moenomycin analogs, methods of synthesis, and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-12-10 | — | — | US | disclosed |
| US-20110136759-A1 | MOENOMYCIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166594-A1 | MOENOMYCIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF | MSN, MGAM, NISCH | TSHR 4135/4885HTT 3289/4885ALDH1A1 4636/4885 |
| US-20110136759-A1 | MOENOMYCIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF | MSN, MGAM, NISCH | TSHR 4135/4885HTT 3289/4885ALDH1A1 4636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.