SCHEMBL8940495

SCHEMBL8940495

COc1ccc(COC[C@H](O)CO)cc1OC

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.60
HTT P42858 2/20 0.60
ALDH1A1 P00352 4/20 0.58
LMNA P02545 3/20 0.53
STAT3 P40763 1/20 0.53
AGTR1 P30556 1/20 0.51
CYP1A2 P05177 1/20 0.51
CA2 P00918 2/20 0.49
CA1 P00915 1/20 0.48
SMN1; SMN2 Q16637 2/20 0.47
NPC1 O15118 1/20 0.47
TP53 P04637 1/20 0.47
RAB9A P51151 1/20 0.47
KDM4E B2RXH2 1/20 0.47
MEN1 O00255 1/20 0.47
GAA P10253 1/20 0.47
MAPT P10636 1/20 0.47
KMT2A Q03164 1/20 0.47
LDHA P00338 1/20 0.46
PPARG P37231 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8844963 1.00 TSHR (0.60) TSHRHTTALDH1A1LMNASTAT3
SCHEMBL14830221 0.88 TSHR (0.60) TSHRHTTALDH1A1LMNASTAT3
SCHEMBL14830246 0.88 TSHR (0.60) TSHRHTTALDH1A1LMNASTAT3
SCHEMBL8940504 0.86 TSHR (0.58) TSHRHTTALDH1A1LMNASTAT3
SCHEMBL8940508 0.86 TSHR (0.58) TSHRHTTALDH1A1LMNASTAT3
SCHEMBL9272295 0.83 ALDH1A1 (0.46) TSHRHTTALDH1A1LMNAAGTR1
SCHEMBL2029904 0.80 TSHR (0.56) TSHRHTTALDH1A1LMNASTAT3
SCHEMBL2029906 0.80 TSHR (0.56) TSHRHTTALDH1A1LMNASTAT3
SCHEMBL9561046 0.80 LDHA (0.60) HTTALDH1A1LMNASTAT3AGTR1
SCHEMBL4336649 0.80 CA2 (0.59) TSHRHTTALDH1A1STAT3CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0654995-B1 4-OXA-1-AZABICYCLO (3,2,0) HEPTAN-7-ONE DERIVATIVES AS ANTITUMOR AGENTS TAIHO PHARMACEUTICAL CO LTD (JP) 1996-10-23 EP disclosed
US-5561126-A OXAPENAMS HAVING CHEMICAL STABILITY; ANTICARCINOGENIC AGENTS; LEUKEMIA TAIHO PHARMACEUTICAL CO., LTD. (JP) 1996-10-01 US disclosed
WO-1994001109-A1 4-OXA-1-AZABICYCLO [3,2,0] HEPTAN-7-ONE DERIVATIVES AS ANTITUMOR AGENTS TAIHO PHARMACEUTICAL CO. LTD. (JP) 1994-01-20 WO disclosed