Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | MMP12 | P39900 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | OGA | O60502 | 1/20 | 0.31 |
| ▸ | LGALS3 | P17931 | 3/20 | 0.30 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.30 |
| ▸ | LGALS7; LGALS7B | P47929 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20299966 | 0.91 | LMNA (0.44) | MMP9MMP12LMNAKMT2APOLB | |
| SCHEMBL16441832 | 0.84 | OGA (0.44) | MMP9MMP12LMNAKMT2APOLB | |
| SCHEMBL16441939 | 0.81 | LMNA (0.40) | MMP9MMP12LMNAKMT2APOLB | |
| SCHEMBL24699769 | 0.79 | LMNA (0.48) | MMP9MMP12LMNAKMT2APOLB | |
| SCHEMBL24645816 | 0.79 | LMNA (0.48) | MMP9MMP12LMNAKMT2APOLB | |
| SCHEMBL20299971 | 0.79 | MAPK1 (0.53) | LMNAKMT2APOLBALDH1A1CYP3A4 | |
| SCHEMBL10903487 | 0.79 | CA9 (0.41) | MMP9MMP12LMNAKMT2APOLB | |
| SCHEMBL10903484 | 0.79 | CA9 (0.41) | MMP9MMP12LMNAKMT2APOLB | |
| SCHEMBL21518245 | 0.78 | LMNA (0.45) | MMP9MMP12LMNAKMT2APOLB | |
| SCHEMBL17230163 | 0.78 | LMNA (0.53) | MMP9MMP12LMNAKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558323-A1 | SPECIFIC TLR4 ANTAGONIST IN THE TREATMENT OF MULTIPLE MYELOMA | Etablissement Français du Sang (FR) | 2019-10-30 | — | — | EP | disclosed |
| WO-2018115476-A1 | SPECIFIC TLR4 ANTAGONIST IN THE TREATMENT OF MULTIPLE MYELOMA | ETABLISSEMENT FRANÇAIS DU SANG (FR) | 2018-06-28 | — | — | WO | disclosed |