Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LGALS8 | O00214 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | TLR4 | O00206 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21518247 | 0.92 | LMNA (0.49) | LMNAKMT2AMMP9MMP12ALDH1A1 | |
| SCHEMBL16441832 | 0.90 | OGA (0.44) | LMNAKMT2AMMP9MMP12ALDH1A1 | |
| SCHEMBL16441939 | 0.83 | LMNA (0.40) | LMNAKMT2AMMP9MMP12ALDH1A1 | |
| SCHEMBL27210426 | 0.82 | OGA (0.50) | LMNAKMT2AOGATHRBCYP2D6 | |
| SCHEMBL24645816 | 0.82 | LMNA (0.48) | LMNAKMT2AMMP9MMP12ALDH1A1 | |
| SCHEMBL21332151 | 0.80 | CYP3A4 (0.41) | LMNAKMT2AALDH1A1POLBOGA | |
| SCHEMBL21518244 | 0.80 | LMNA (0.49) | LMNAKMT2AMMP9MMP12ALDH1A1 | |
| SCHEMBL24699769 | 0.79 | LMNA (0.48) | LMNAKMT2AMMP9MMP12ALDH1A1 | |
| SCHEMBL20299969 | 0.78 | MMP9 (0.40) | LMNAKMT2AMMP9MMP12ALDH1A1 | |
| SCHEMBL21332348 | 0.78 | CYP3A4 (0.39) | LMNAKMT2AALDH1A1POLBOGA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558323-A1 | SPECIFIC TLR4 ANTAGONIST IN THE TREATMENT OF MULTIPLE MYELOMA | Etablissement Français du Sang (FR) | 2019-10-30 | — | — | EP | disclosed |