Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 4/20 | 0.44 |
| ▸ | USP25 | Q9UHP3 | 3/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3372357 | 0.86 | PTGDR2 (0.53) | USP28USP25PTGDR2SLC6A4MEN1 | |
| SCHEMBL30468149 | 0.85 | SLC6A4 (0.38) | USP28USP25PTGDR2SLC6A4MEN1 | |
| SCHEMBL28755481 | 0.83 | PTGDR2 (0.40) | USP28USP25PTGDR2SLC6A4MAPK1 | |
| SCHEMBL3853386 | 0.81 | SLC6A4 (0.40) | USP28USP25PTGDR2SLC6A4MEN1 | |
| SCHEMBL29439695 | 0.79 | CCR5 (0.49) | USP28USP25PTGDR2SLC6A4MEN1 | |
| SCHEMBL3854039 | 0.79 | CCR5 (0.49) | USP28USP25PTGDR2SLC6A4MEN1 | |
| SCHEMBL18085151 | 0.78 | SMN1; SMN2 (0.40) | SLC6A4MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL4110909 | 0.78 | EPHX2 (0.40) | USP28USP25MAOAMAOBALPL | |
| SCHEMBL6044488 | 0.77 | KDM4E (0.53) | MEN1KMT2ASMN1; SMN2HTTHSD17B10 | |
| SCHEMBL3357880 | 0.77 | USP28 (0.40) | USP28USP25PTGDR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558298-A1 | ANTIDIABETIC SPIROCHROMAN COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2019-10-30 | — | — | EP | disclosed |
| WO-2018118670-A1 | ANTIDIABETIC SPIROCHROMAN COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |