Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 2/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.36 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.35 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15207753 | 0.85 | SYK (0.36) | ZAP70SYKSRCCDK2GSK3B | |
| SCHEMBL21783 | 0.79 | AURKA (0.43) | ZAP70SYKSRCCDK2SMN1; SMN2 | |
| SCHEMBL20261 | 0.74 | KDM4E (0.47) | ZAP70SYKBCDIN3DSMN1; SMN2ALDH1A1 | |
| SCHEMBL20306 | 0.74 | JAK2 (0.34) | ZAP70SYKSRCEGFRFGFR1 | |
| SCHEMBL21195 | 0.73 | SYK (0.42) | ZAP70SYKNUAK1 | |
| SCHEMBL20643 | 0.72 | KCNH3 (0.46) | PLK1CDK4MAPK1MEN1USP2 | |
| SCHEMBL22264 | 0.72 | NOS1 (0.38) | ZAP70SYKSRCCDK2PLK1 | |
| SCHEMBL19883 | 0.71 | TP53 (0.42) | ZAP70SYKSRCCDK2SMN1; SMN2 | |
| SCHEMBL15206978 | 0.68 | BRD4 (0.41) | CDK2PLK1EGFRMAPK1SMN1; SMN2 | |
| SCHEMBL19497 | 0.68 | TNK2 (0.46) | SRCCDK2PLK1CDK4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609098-B1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-07-13 | — | — | EP | claimed |