Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.34 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 6/20 | 0.34 |
| ▸ | SYK | P43405 | 6/20 | 0.34 |
| ▸ | JAK3 | P52333 | 4/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15207754 | 0.85 | KDR (0.34) | JAK2ZAP70SYKSRC | |
| SCHEMBL21784 | 0.79 | SLC2A1 (0.42) | PTK2EGFR | |
| SCHEMBL20305 | 0.74 | ZAP70 (0.38) | BCDIN3DZAP70SYKSRCKARS1 | |
| SCHEMBL20262 | 0.74 | MAPT (0.46) | BCDIN3DEGFR | |
| SCHEMBL21196 | 0.72 | SYK (0.39) | ZAP70SYK | |
| SCHEMBL20644 | 0.72 | KCNH3 (0.44) | JAK2JAK3 | |
| SCHEMBL22265 | 0.71 | NOS1 (0.44) | SYK | |
| SCHEMBL19884 | 0.70 | MAPT (0.41) | PTK2SYK | |
| SCHEMBL23412 | 0.69 | ZAP70 (0.53) | JAK2PTK2ZAP70SYKKARS1 | |
| SCHEMBL19908 | 0.68 | MAPT (0.44) | JAK2PTK2BCDIN3DJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609098-B1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-07-13 | — | — | EP | claimed |