Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 10/20 | 0.56 |
| ▸ | CTSK | P43235 | 8/20 | 0.56 |
| ▸ | MME | P08473 | 5/20 | 0.50 |
| ▸ | CTSB | P07858 | 3/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16941445 | 0.91 | CTSS (0.58) | CTSSCTSKMMECTSBCTSL | |
| SCHEMBL18874682 | 0.89 | MME (0.52) | CTSSCTSKMMECTSBCTSL | |
| SCHEMBL18874742 | 0.89 | MME (0.53) | CTSSCTSKMMECTSBCTSL | |
| SCHEMBL11970064 | 0.86 | MME (0.54) | CTSSCTSKMMECTSBCTSL | |
| SCHEMBL18411073 | 0.86 | MME (0.54) | CTSSCTSKMMECTSBCTSL | |
| SCHEMBL11969730 | 0.86 | MME (0.54) | CTSSCTSKMMECTSBCTSL | |
| SCHEMBL20099586 | 0.86 | MME (0.55) | CTSSCTSKMMECTSBCTSL | |
| SCHEMBL18626431 | 0.85 | CTSS (0.51) | CTSSCTSKMMECTSBCTSL | |
| SCHEMBL16941039 | 0.85 | MME (0.69) | CTSSCTSKMMECTSBCTSL | |
| SCHEMBL20099592 | 0.85 | MME (0.57) | CTSSCTSKMMECTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005740-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10005740-B2 | Neprilysin inhibitors | MME, REN, AGTR1 | CTSS 91/4885CTSK 176/4885MME 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.