Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALAD | P13716 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6632966 | 0.84 | IKBKB (0.41) | MAP4K4NPC1ALDH1A1KDM4E | |
| SCHEMBL3983853 | 0.83 | HSD17B10 (0.47) | AGTR1AGTR2RAB9AALDH1A1MAPT | |
| SCHEMBL27605316 | 0.83 | KMT2A (0.44) | AGTR1AGTR2RAB9AALDH1A1MAPT | |
| SCHEMBL8138770 | 0.83 | BCL2L1 (0.48) | AGTR1AGTR2MAP4K4NPC1RAB9A | |
| SCHEMBL1549765 | 0.82 | KMT2A (0.46) | AGTR1AGTR2TSHR | |
| SCHEMBL137803 | 0.81 | AGTR1 (0.42) | AGTR1AGTR2NPC1RAB9AALDH1A1 | |
| SCHEMBL2318665 | 0.81 | SMN1; SMN2 (0.42) | AGTR1AGTR2MAP4K4NPC1RAB9A | |
| SCHEMBL27605308 | 0.81 | PTPN1 (0.41) | AGTR1AGTR2TSHRALDH1A1KDM4E | |
| SCHEMBL244322 | 0.81 | GPR35 (0.43) | AGTR1AGTR2KDM4EMAPTNOTUM | |
| SCHEMBL5634176 | 0.78 | MAPK14 (0.49) | AGTR1AGTR2TSHRMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103265511-A | Synthetic method of A-803467 key intermediate | UNIV ZHENGZHOU | 2013-08-28 | — | — | CN | claimed |
| CN-102746282-B | N-5-substituted phenyl-2-furoyl compounds, preparation method and application thereof | UNIV CHINA AGRICULTURAL | 2014-08-20 | — | — | CN | disclosed |
| EP-2512238-A1 | FUSED TRICYCLIC COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| CN-102746282-A | N-5-substituted phenyl-2-furoyl compounds, preparation method and application thereof | UNIV CHINA AGRICULTURAL | 2012-10-24 | — | — | CN | disclosed |
| WO-2011075375-A1 | FUSED TRICYCLIC COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |
| CN-100543022-C | 2-furancarboxylic acid hydrazide compound and contain the pharmaceutical composition of this compound | DAINIPPON PHARMACEUTICAL CO (JP) | 2009-09-23 | — | — | CN | disclosed |
| CN-1628111-A | 2-furancarboxylic acid hydrazides and pharmaceutical compositions containing the same | DAINIPPON PHARMACEUTICAL CO (JP) | 2005-06-15 | — | — | CN | disclosed |
| US-20050014765-A1 | Aryl-heteroaromatic products, compositions comprising them and use | AVENTIS PHARMA S.A. (FR) | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014765-A1 | Aryl-heteroaromatic products, compositions comprising them and use | AHR, ARNT, MYC | AGTR1 2886/4885AGTR2 2263/4885ALOX15 777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.