Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 14/20 | 0.78 |
| ▸ | HTT | P42858 | 4/20 | 0.76 |
| ▸ | WRN | Q14191 | 3/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | GAA | P10253 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.76 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.76 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.76 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.76 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12642191 | 0.88 | BLM (0.78) | HPNBLMHTTWRNKDM4E | |
| SCHEMBL11875081 | 0.88 | BLM (0.80) | HPNBLMHTTWRNKDM4E | |
| SCHEMBL8559872 | 0.84 | HTT (0.73) | HPNBLMHTTWRNKDM4E | |
| SCHEMBL8561964 | 0.80 | HTT (0.75) | HPNBLMHTTWRNKDM4E | |
| SCHEMBL8569537 | 0.78 | HTT (1.00) | HPNBLMHTTWRNKDM4E | |
| SCHEMBL3467385 | 0.77 | RAB9A (0.69) | HPNBLMHTTWRNKDM4E | |
| SCHEMBL24232837 | 0.76 | BLM (0.80) | BLMHTTWRNKDM4EMCL1 | |
| SCHEMBL8563911 | 0.75 | RAB9A (0.74) | HPNBLMHTTWRNKDM4E | |
| SCHEMBL8561139 | 0.75 | HTT (0.67) | HPNBLMHTTWRNKDM4E | |
| SCHEMBL18824201 | 0.75 | HSD17B10 (0.61) | HPNBLMHTTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9182402-B2 | Hepsin inhibitors | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2015-11-10 | — | — | US | disclosed |
| US-9182402-B2 | Hepsin inhibitors | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2015-11-10 | — | — | US | disclosed |
| US-20140127127-A1 | HEPSIN INHIBITORS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2014-05-08 | — | — | US | disclosed |
| US-20140127127-A1 | HEPSIN INHIBITORS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2014-05-08 | — | — | US | disclosed |
| US-8664266-B2 | Hepsin inhibitors | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2014-03-04 | — | — | US | disclosed |
| US-20130289105-A1 | HEPSIN INHIBITORS | FRED HUTCHINSON CANCER CENTER | 2013-10-31 | — | — | US | disclosed |
| US-8450334-B2 | Hepsin inhibitors | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2013-05-28 | — | — | US | disclosed |
| US-20110144139-A1 | HEPSIN INHIBITORS | FRED HUTCHINSON CANCER RESEARCH CENTER | 2011-06-16 | — | — | US | disclosed |
| WO-2009151920-A2 | HEPSIN INHIBITORS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140127127-A1 | HEPSIN INHIBITORS | HPN, TMPRSS2, SPINT2 | HPN 1/4885BLM 4402/4885HTT 2265/4885 |
| US-20110144139-A1 | HEPSIN INHIBITORS | HPN, TMPRSS2, SPINT2 | HPN 1/4885BLM 4402/4885HTT 2265/4885 |
| US-20130289105-A1 | HEPSIN INHIBITORS | HPN, TMPRSS2, SPINT2 | HPN 1/4885BLM 4402/4885HTT 2265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.