Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16258908 | 0.83 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTMEN1LMNAKMT2A | |
| SCHEMBL10140470 | 0.78 | KCNA3 (0.32) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1313112 | 0.73 | LOXL2 (0.51) | SMN1; SMN2MAPTKDM4EMEN1LMNA | |
| SCHEMBL505474 | 0.69 | TACR1 (0.38) | MAPTLMNAKMT2AALDH1A1HTT | |
| SCHEMBL9435638 | 0.68 | CYP4F2 (0.50) | SMN1; SMN2MAPTKDM4ELMNAKMT2A | |
| SCHEMBL20742521 | 0.68 | XDH (0.42) | SMN1; SMN2LMNAFAAH | |
| SCHEMBL6472720 | 0.67 | KDM4E (0.43) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL10172623 | 0.67 | ALDH1A1 (0.52) | SMN1; SMN2MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL11298531 | 0.67 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTMEN1LMNAKMT2A | |
| SCHEMBL8128802 | 0.67 | KDM4E (0.44) | SMN1; SMN2MAPTKDM4EMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805939-B1 | Heterocyclic compounds as factor IXA inhibitors. | MERCK SHARP & DOHME (US) | 2018-06-27 | — | — | EP | disclosed |