Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 5/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20312244 | 0.83 | CYP2C9 (0.40) | CYP2D6CYP1A2CYP2C9ALDH1A1EPHX1 | |
| SCHEMBL22369248 | 0.74 | EPHX1 (0.39) | CYP2D6CYP1A2CYP2C9ALDH1A1EPHX1 | |
| SCHEMBL22971692 | 0.70 | CYP2C9 (0.37) | CYP2D6CYP1A2CYP2C9ALDH1A1DPP4 | |
| SCHEMBL11990216 | 0.67 | CYP2D6 (0.44) | CYP2D6CYP1A2CYP2C9EPHX1THRB | |
| SCHEMBL19185028 | 0.66 | GAA (0.51) | ALDH1A1TSHRTHRBATML3MBTL1 | |
| SCHEMBL16766758 | 0.66 | CDC25A (0.38) | NR1H4 | |
| SCHEMBL12439392 | 0.66 | CHRNB2 (0.42) | CYP2D6CYP1A2CYP2C9ALDH1A1EPHX1 | |
| SCHEMBL13709104 | 0.65 | EPHX1 (0.33) | CYP2D6CYP1A2CYP2C9ALDH1A1DPP8 | |
| SCHEMBL2603248 | 0.65 | CYP1A2 (0.45) | CYP2D6CYP1A2CYP2C9ALDH1A1EPHX1 | |
| SCHEMBL23714589 | 0.63 | EPHX1 (0.41) | CYP2D6CYP1A2CYP2C9ALDH1A1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202390-B2 | Heteroaryl substituted aminopyridine compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-02-12 | — | — | US | disclosed |
| US-20180179213-A1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2018-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202390-B2 | Heteroaryl substituted aminopyridine compounds | IRAK4, IRAK3, IRAK2 | CYP2D6 2331/4885CYP1A2 2119/4885CYP2C9 2574/4885 |
| US-20180179213-A1 | HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS | IRAK4, IRAK3, IRAK2 | CYP2D6 2331/4885CYP1A2 2119/4885CYP2C9 2574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.