Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18634102 | 0.75 | NOS2 (0.35) | NOS2CCR1CCR5CCR8NOS3 | |
| SCHEMBL21216438 | 0.73 | — | — | |
| SCHEMBL23732288 | 0.73 | NOS2 (0.34) | NOS2CCR1CCR5CCR8NOS3 | |
| SCHEMBL18760647 | 0.73 | PLAU (0.33) | — | |
| SCHEMBL25792605 | 0.72 | NOS3 (0.46) | NOS2CCR1CCR5CCR8NOS3 | |
| SCHEMBL19953987 | 0.71 | NOS2 (0.31) | NOS2CCR1CCR5CCR8NOS3 | |
| SCHEMBL20967588 | 0.70 | CCR1 (0.50) | CCR1CCR5CCR8 | |
| SCHEMBL13771122 | 0.69 | NOS2 (0.31) | NOS2CCR1CCR5CCR8NOS3 | |
| SCHEMBL14421997 | 0.69 | NOS2 (0.31) | NOS2CCR1CCR5CCR8NOS3 | |
| SCHEMBL24848485 | 0.69 | SMN1; SMN2 (0.32) | NOS2CCR1CCR5CCR8NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10221135-B2 | 1,4-substituted piperidine derivatives | 89BIO LTD (IL) | 2019-03-05 | — | — | US | disclosed |
| US-20180179159-A1 | 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES | CEPHALON LLC | 2018-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10221135-B2 | 1,4-substituted piperidine derivatives | FASN, CES1, CPT1A | NOS2 462/4885CCR1 2639/4885CCR5 2780/4885 |
| US-20180179159-A1 | 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES | FASN, CES1, CPT1A | NOS2 444/4885CCR1 2696/4885CCR5 2650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.