Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20323891 | 0.87 | KDM4E (0.46) | ALDH1A1KDM4ETDP1CYP2D6KMT2A | |
| Ethylene SCHEMBL27903211 | 0.76 | ALDH1A1 (0.50) | ALDH1A1KDM4ETDP1CYP2D6CYP1A2 | |
| SCHEMBL20128701 | 0.75 | KDM4E (0.43) | ALDH1A1KDM4ETDP1CYP2D6CYP1A2 | |
| SCHEMBL11663045 | 0.74 | SLC6A4 (0.47) | CYP2D6KMT2AMEN1 | |
| SCHEMBL24021874 | 0.73 | ALDH1A1 (0.47) | ALDH1A1KDM4ETDP1CYP2D6CYP1A2 | |
| SCHEMBL11895109 | 0.73 | DRD2 (0.63) | DRD2DRD4 | |
| SCHEMBL12250968 | 0.72 | CYP2D6 (0.41) | ALDH1A1KDM4ETDP1CYP2D6CYP1A2 | |
| SCHEMBL7616010 | 0.71 | DRD2 (0.66) | DRD2DRD4 | |
| SCHEMBL11466475 | 0.71 | CHRNB4 (0.55) | ALDH1A1CYP2D6MAPK1HRH3 | |
| SCHEMBL11447824 | 0.70 | CHRNB4 (0.54) | ALDH1A1CYP2D6MAPK1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119448-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |