Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.60 |
| ▸ | DPP4 | P27487 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MPO | P05164 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | MMP3 | P08254 | 1/20 | 0.55 |
| ▸ | SOS1 | Q07889 | 5/20 | 0.54 |
| ▸ | KRAS | P01116 | 1/20 | 0.54 |
| ▸ | ARG1 | P05089 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2032411 | 1.00 | SMYD3 (0.60) | SMYD3DPP4MEN1KMT2AKDM4E | |
| SCHEMBL8689594 | 0.84 | DPP4 (0.56) | SMYD3DPP4MEN1KMT2AKDM4E | |
| SCHEMBL8689586 | 0.84 | DPP4 (0.56) | SMYD3DPP4MEN1KMT2AKDM4E | |
| SCHEMBL15084031 | 0.84 | MMP3 (0.59) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL9452845 | 0.84 | KMT2A (0.64) | SMYD3DPP4MEN1KMT2AKDM4E | |
| SCHEMBL7420410 | 0.84 | DPP4 (0.58) | SMYD3DPP4MEN1KMT2AKDM4E | |
| SCHEMBL27633966 | 0.83 | MEN1 (0.62) | SMYD3DPP4MEN1KMT2AKDM4E | |
| SCHEMBL3788185 | 0.82 | MEN1 (0.61) | SMYD3DPP4MEN1KMT2AKDM4E | |
| SCHEMBL3788187 | 0.82 | MEN1 (0.61) | SMYD3DPP4MEN1KMT2AKDM4E | |
| SCHEMBL15081812 | 0.82 | MMP3 (0.56) | SMYD3MEN1KMT2ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883721-B2 | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof | MCGILL UNIVERSITY (CA) | 2014-11-11 | — | — | US | claimed |
| US-20120135918-A1 | METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF | MCGILL UNIVERSITY (CA) | 2012-05-31 | — | — | US | claimed |
| US-20090069245-A1 | GHRELIN/GROWTH HORMONE RELEASING PEPTIDE/GROWTH HORMONE SECRETATOGUE RECEPTOR ANTAGONISTS AND USES THEREOF | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2009-03-12 | — | — | US | claimed |
| US-10550377-B2 | Suppression of prostate cancer using a targeted clostridial neurotoxin | IPSEN BIOINNOVATION LIMITED (GB) | 2020-02-04 | — | — | US | disclosed |
| EP-2719392-B1 | Fusion proteins for use in the treatment of acromegaly | IPSEN BIOINNOVATION LTD (GB) | 2019-07-24 | — | — | EP | disclosed |
| US-20190127718-A1 | SUPPRESSION OF CANCER | IPSEN BIOINNOVATION LIMITED (GB) | 2019-05-02 | — | — | US | disclosed |
| EP-3473643-A1 | FUSION PROTEINS FOR USE IN THE TREATEMNT OF CANCER | Ipsen Bioinnovation Limited (GB) | 2019-04-24 | — | — | EP | disclosed |
| EP-2310029-B1 | Fusion proteins for use in the treatment of cancer | IPSEN BIOINNOVATION LTD (GB) | 2019-04-03 | — | — | EP | disclosed |
| US-10240138-B2 | Polypeptides that bind to and inhibit secretion from growth hormone secreting cells | IPSEN BIOINNOVATION LIMITED | 2019-03-26 | — | — | US | disclosed |
| US-10113159-B2 | Suppression of cancer | IPSEN BIOINNOVATION LIMITED (GB) | 2018-10-30 | — | — | US | disclosed |
| EP-3241560-A1 | SUPPRESSION OF CANCER | Ipsen Bioinnovation Limited (GB) | 2017-11-08 | — | — | EP | disclosed |
| EP-2364166-B1 | SUPPRESSION OF CANCER | SYNTAXIN LTD (GB) | 2013-05-15 | — | — | EP | disclosed |
| US-20120135918-A1 | METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF | MCGILL UNIVERSITY (CA) | 2012-05-31 | — | — | US | disclosed |
| US-20110171191-A1 | SUPPRESSION OF NEUROENDOCRINE DISEASES | SYNTAXIN LIMITED (GB) | 2011-07-14 | — | — | US | disclosed |
| US-20110165137-A1 | SUPPRESSION OF CANCERS | SYNTAXIN LIMITED (GB) | 2011-07-07 | — | — | US | disclosed |
| US-20110158973-A1 | SUPPRESSION OF CANCERS | SYNTAXIN LIMITED (GB) | 2011-06-30 | — | — | US | disclosed |
| US-20110160135-A1 | SUPPRESSION OF NEUROENDOCRINE DISEASES | SYNTAXIN LIMITED (GB) | 2011-06-30 | — | — | US | disclosed |
| WO-2010132580-A2 | METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2010-11-18 | — | — | WO | disclosed |
| US-20090069245-A1 | GHRELIN/GROWTH HORMONE RELEASING PEPTIDE/GROWTH HORMONE SECRETATOGUE RECEPTOR ANTAGONISTS AND USES THEREOF | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2009-03-12 | — | — | US | disclosed |
| WO-2007127457-A9 | GHRELIN/GROWTH HORMONE RELEASING PEPTIDE/GROWTH HORMONE SECRETATOGUE RECEPTOR ANTAGONISTS AND USES THEREOF | UNIV TULANE (US) | 2008-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135918-A1 | METHODS OF INHIBITING THE GHRELIN/GROWTH HORMONE SECRETATOGUE RECEPTOR PATHWAY AND USES THEREOF | GHSR, GIPR, GHRHR | SMYD3 3189/4885DPP4 394/4885MEN1 1896/4885 |
| US-20090069245-A1 | GHRELIN/GROWTH HORMONE RELEASING PEPTIDE/GROWTH HORMONE SECRETATOGUE RECEPTOR ANTAGONISTS AND USES THEREOF | GHSR, GHRHR, GIPR | SMYD3 4418/4885DPP4 686/4885MEN1 782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.