Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.42 |
| ▸ | GRK6 | P43250 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2032453 | 1.00 | RPS6KB1 (0.47) | RPS6KB1SIRT2SIRT1GRK6NPC1 | |
| SCHEMBL2031010 | 0.85 | RPS6KB1 (0.49) | RPS6KB1SIRT2SIRT1GRK6NPC1 | |
| SCHEMBL2031012 | 0.85 | RPS6KB1 (0.49) | RPS6KB1SIRT2SIRT1GRK6NPC1 | |
| SCHEMBL22382488 | 0.84 | RPS6KB1 (0.51) | RPS6KB1SIRT2SIRT1GRK6NPC1 | |
| SCHEMBL2030741 | 0.84 | L3MBTL1 (0.57) | RPS6KB1SIRT2SIRT1NPC1RAB9A | |
| SCHEMBL2031672 | 0.79 | MET (0.39) | RPS6KB1MAPTALDH1A1 | |
| SCHEMBL2031673 | 0.79 | MET (0.39) | RPS6KB1MAPTALDH1A1 | |
| SCHEMBL21310910 | 0.77 | GRK6 (0.46) | RPS6KB1GRK6NPC1RAB9AMEN1 | |
| SCHEMBL17582784 | 0.77 | RPS6KB1 (0.48) | RPS6KB1GRK6NPC1L3MBTL1PDE2A | |
| SCHEMBL21310911 | 0.76 | ALDH1A1 (0.52) | RPS6KB1SIRT2SIRT1GRK6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293923-B2 | Indazole derivatives as modulators of interleukin-1 receptor-associated kinase | BIOGEN IDEC MA INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-20110152260-A1 | Indazole derivatives as modulators of interleukin-1 receptor-associated kinase | BIOGEN IDEC MA INC. (US) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152260-A1 | Indazole derivatives as modulators of interleukin-1 receptor-associated kinase | IRAK1, IRAK2, IRAK3 | RPS6KB1 147/4885SIRT2 552/4885SIRT1 305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.