Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.44 |
| ▸ | PGD | P52209 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PGK1 | P00558 | 1/20 | 0.42 |
| ▸ | PGK2 | P07205 | 1/20 | 0.42 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.41 |
| ▸ | LPAR4 | Q99677 | 1/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.41 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.38 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19010230 | 0.79 | — | — | |
| SCHEMBL182785 | 0.79 | — | — | |
| SCHEMBL20326991 | 0.78 | ENPP2 (0.44) | LPAR5PGDALDH1A1TDP1PGK1 | |
| SCHEMBL1286423 | 0.76 | PGK1 (0.58) | LPAR5PGDPGK1PGK2LPAR6 | |
| SCHEMBL4152528 | 0.74 | LPAR5 (0.62) | LPAR5LPAR6LPAR1LPAR4LPAR2 | |
| SCHEMBL20324737 | 0.74 | LPAR5 (0.36) | LPAR5PGDPGK1PGK2LPAR6 | |
| SCHEMBL6045527 | 0.74 | MPI (0.53) | LPAR5PGDPGK1PGK2LPAR6 | |
| SCHEMBL28480885 | 0.73 | LPAR5 (0.65) | LPAR5LPAR6LPAR1LPAR4LPAR2 | |
| SCHEMBL12558548 | 0.73 | LPAR5 (0.55) | LPAR5PGDPGK1PGK2LPAR6 | |
| SCHEMBL5024727 | 0.73 | PGD (0.50) | LPAR5PGDPGK1PGK2LPAR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118664-A1 | COMBINATIONS OF PD-1 ANTAGONISTS AND CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018118665-A1 | CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |