Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | PNP | P00491 | 3/20 | 0.36 |
| ▸ | HPRT1 | P00492 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20324728 | 1.00 | P2RX3 (0.41) | P2RX3PNPHPRT1ALDH1A1LMNA | |
| SCHEMBL21637077 | 0.93 | P2RX3 (0.42) | P2RX3PNPHPRT1ALDH1A1LMNA | |
| SCHEMBL22524029 | 0.91 | P2RX3 (0.41) | P2RX3PNPHPRT1ALDH1A1LMNA | |
| SCHEMBL21133326 | 0.85 | P2RX3 (0.55) | P2RX3PNPHPRT1ALDH1A1LMNA | |
| SCHEMBL20327511 | 0.84 | AHCY (0.41) | P2RX3ALDH1A1 | |
| SCHEMBL20324560 | 0.84 | AHCY (0.41) | P2RX3ALDH1A1 | |
| SCHEMBL18522296 | 0.81 | P2RX3 (0.51) | P2RX3HPRT1 | |
| SCHEMBL20326948 | 0.78 | FUT5 (0.43) | P2RX3 | |
| SCHEMBL22524038 | 0.78 | PNP (0.49) | P2RX3PNPHPRT1 | |
| SCHEMBL21133316 | 0.77 | P2RX3 (0.56) | P2RX3ALDH1A1LMNAALBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118664-A1 | COMBINATIONS OF PD-1 ANTAGONISTS AND CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018118665-A1 | CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |