Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUT5 | Q11128 | 1/20 | 0.49 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.47 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.47 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | STING1 | Q86WV6 | 5/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.44 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | RNASEL | Q05823 | 2/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.43 |
| ▸ | KRAS | P01116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20327591 | 0.91 | FUT5 (0.47) | FUT5P2RY2P2RY4P2RY6TGM2 | |
| SCHEMBL20325247 | 0.89 | FUT5 (0.50) | FUT5P2RY2P2RY4P2RY6TGM2 | |
| SCHEMBL20325243 | 0.84 | FUT5 (0.53) | FUT5P2RY2P2RY4P2RY6TGM2 | |
| SCHEMBL20324586 | 0.84 | RNASEL (0.60) | P2RY2P2RY4P2RY6RNASEL | |
| SCHEMBL20434907 | 0.83 | FUT5 (0.47) | FUT5P2RY2P2RY4P2RY6TGM2 | |
| SCHEMBL22326749 | 0.83 | FUT5 (0.53) | FUT5TGM2STING1NT5ERNASEL | |
| SCHEMBL2922052 | 0.82 | POLB (0.61) | FUT5P2RY2P2RY4P2RY6TGM2 | |
| SCHEMBL20442307 | 0.82 | POLB (0.61) | FUT5P2RY2P2RY4P2RY6TGM2 | |
| SCHEMBL20325245 | 0.82 | STING1 (0.54) | FUT5TGM2STING1POLBNT5E | |
| SCHEMBL20324732 | 0.81 | P2RY2 (0.52) | FUT5P2RY2P2RY4P2RY6TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118665-A1 | CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018118664-A1 | COMBINATIONS OF PD-1 ANTAGONISTS AND CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |