SCHEMBL2922052

SCHEMBL2922052

Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)O)C[C@H]2O)c(=O)[nH]1

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.61
▸ NT5E P21589 1/20 0.60
▸ TGM2 P21980 1/20 0.58
▸ IMPDH2 P12268 6/20 0.57
▸ TAS1R3 Q7RTX0 2/20 0.54
▸ TAS1R1 Q7RTX1 2/20 0.54
▸ IMPDH1 P20839 2/20 0.54
▸ FUT5 Q11128 1/20 0.54
▸ P2RY2 P41231 1/20 0.53
▸ P2RY4 P51582 1/20 0.53
▸ P2RY6 Q15077 1/20 0.53
▸ PNP P00491 1/20 0.52
▸ HINT1 P49773 1/20 0.51
▸ KRAS P01116 2/20 0.51
▸ STING1 Q86WV6 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20442307 1.00 POLB (0.61) POLBNT5ETGM2IMPDH2TAS1R3
Deoxy Adenosinediphosphate SCHEMBL5827749 0.93 TGM2 (0.63) POLBNT5ETGM2IMPDH2TAS1R3
Deoxy Adenosinediphosphate SCHEMBL5827743 0.93 TGM2 (0.63) POLBNT5ETGM2IMPDH2TAS1R3
SCHEMBL22352197 0.93 NT5E (0.58) POLBNT5ETGM2IMPDH2TAS1R3
SCHEMBL25712474 0.92 TGM2 (0.62) POLBNT5ETGM2IMPDH2FUT5
SCHEMBL7065119 0.92 TGM2 (0.62) POLBNT5ETGM2IMPDH2FUT5
SCHEMBL1913809 0.92 TGM2 (0.62) POLBNT5ETGM2IMPDH2FUT5
SCHEMBL22352187 0.91 TGM2 (0.59) POLBNT5ETGM2IMPDH2TAS1R3
SCHEMBL19147349 0.91 NT5E (0.56) POLBNT5ETGM2IMPDH2FUT5
SCHEMBL20698981 0.90 NT5E (0.57) POLBNT5ETGM2IMPDH2TAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0048022-B1 ENHANCER OF ANTI-TUMOR EFFECT Yamasa Shoyu Kabushiki Kaisha (JP) 1985-01-09 — — EP claimed
US-4432348-A 3'-DEOXYGUANOSINE-5'-MONOPHOSPHATE OR 3'-DEOXYADENOSINE-5'-MONOPHOSPHATE YAMASA SHOYU KABUSHIKI KAISHA (JP) 1984-02-21 — — US claimed
EP-0048022-A2 Enhancer of anti-tumor effect Yamasa Shoyu Kabushiki Kaisha (JP) 1982-03-24 — — EP claimed
JP-57067518-A — — None — — JP disclosed
US-20210139604-A1 COMPOSITIONS OF ANTIBODY CONSTRUCT-AGONIST CONJUGATES AND METHODS OF USE THEREOF OPI VI - IP HOLDCO LLC 2021-05-13 — — US disclosed
EP-1734046-B1 Sulfopyranosylacylglycerol derivatives for use in combination with irradiation in an anti-tumor radiation treatment TOYO SUISAN KAISHA (JP) 2010-09-01 — — EP disclosed
US-7074596-B2 Synthesis and use of anti-reverse mRNA cap analogues BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) 2006-07-11 — — US disclosed
US-20030194759-A1 Synthesis and use of anti-reverse mRBA cap analogues DARZYNKIEWICZ, EDWARD (PL) 2003-10-16 — — US disclosed
EP-0048022-B1 ENHANCER OF ANTI-TUMOR EFFECT Yamasa Shoyu Kabushiki Kaisha (JP) 1985-01-09 — — EP disclosed
US-4432348-A 3'-DEOXYGUANOSINE-5'-MONOPHOSPHATE OR 3'-DEOXYADENOSINE-5'-MONOPHOSPHATE YAMASA SHOYU KABUSHIKI KAISHA (JP) 1984-02-21 — — US disclosed
US-4432348-A 3'-DEOXYGUANOSINE-5'-MONOPHOSPHATE OR 3'-DEOXYADENOSINE-5'-MONOPHOSPHATE YAMASA SHOYU KABUSHIKI KAISHA (JP) 1984-02-21 — — US disclosed
JP-S5767518-A RADIOSENSITIZING AGENT OR AGENT FOR INCREASING EFFECT OF RADIOMIMETIC SUBSTANCE YAMASA SHOYU CO LTD 1982-04-24 — — JP disclosed
EP-0048022-A2 Enhancer of anti-tumor effect Yamasa Shoyu Kabushiki Kaisha (JP) 1982-03-24 — — EP disclosed
EP-0048022-A2 Enhancer of anti-tumor effect Yamasa Shoyu Kabushiki Kaisha (JP) 1982-03-24 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210139604-A1 COMPOSITIONS OF ANTIBODY CONSTRUCT-AGONIST CONJUGATES AND METHODS OF USE THEREOF STING1, CGAS, TLR7 POLB 3219/4885NT5E 330/4885TGM2 2378/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback