Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 4/20 | 0.33 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24539018 | 0.87 | POLB (0.41) | P2RY1P2RY2SRCSMN1; SMN2POLB | |
| SCHEMBL20324585 | 0.83 | DNPH1 (0.38) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL20324789 | 0.80 | STING1 (0.31) | P2RY1P2RY2SRCSMN1; SMN2POLB | |
| SCHEMBL23052587 | 0.76 | NT5E (0.49) | P2RY1POLBP2RX1P2RX3ALDH1A1 | |
| SCHEMBL20324787 | 0.73 | POLB (0.44) | P2RY2POLBSTING1 | |
| SCHEMBL22524022 | 0.72 | POLB (0.43) | P2RY2POLBSTING1 | |
| SCHEMBL21637014 | 0.72 | DNPH1 (0.38) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL17106826 | 0.71 | — | — | |
| SCHEMBL17106740 | 0.71 | ADRB1 (0.40) | SMN1; SMN2POLBADORA1PDE4DPDE3A | |
| SCHEMBL20325339 | 0.71 | POLB (0.31) | P2RY1P2RY2SRCSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118664-A1 | COMBINATIONS OF PD-1 ANTAGONISTS AND CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |