⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22692331 | 0.85 | — | — | |
| SCHEMBL22560667 | 0.82 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL18592285 | 0.81 | — | — | |
| SCHEMBL20046545 | 0.80 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL23664688 | 0.78 | — | — | |
| SCHEMBL22374672 | 0.78 | — | — | |
| SCHEMBL22006751 | 0.75 | NAAA (0.32) | — | |
| SCHEMBL17169728 | 0.67 | TDP1 (0.45) | — | |
| SCHEMBL25468162 | 0.66 | TDP1 (0.40) | — | |
| SCHEMBL26852467 | 0.66 | CES2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723717-B2 | Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides | ARVINAS OPERATIONS, INC. (US) | 2020-07-28 | — | — | US | disclosed |
| US-20180179183-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | ARVINAS OPERATIONS, INC. | 2018-06-28 | — | — | US | disclosed |