Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9668422 | 0.95 | GAA (0.58) | L3MBTL1GAATP53TSHRPLA2G4B | |
| SCHEMBL9680607 | 0.95 | GAA (0.58) | L3MBTL1GAATP53TSHRPLA2G4B | |
| SCHEMBL18241699 | 0.91 | L3MBTL1 (0.48) | L3MBTL1GAAPKMMAPTTP53 | |
| SCHEMBL10390474 | 0.89 | GAA (0.51) | L3MBTL1GAATP53TSHRPLA2G4B | |
| SCHEMBL9615211 | 0.86 | GAA (0.66) | L3MBTL1GAATP53TSHRPLA2G4B | |
| SCHEMBL10954272 | 0.86 | MAPT (0.59) | L3MBTL1GAAPKMMAPTTP53 | |
| SCHEMBL19024978 | 0.85 | GAA (0.58) | L3MBTL1GAAPKMMAPTTP53 | |
| SCHEMBL2039841 | 0.85 | L3MBTL1 (0.55) | L3MBTL1GAAPKMMAPTTP53 | |
| SCHEMBL12321296 | 0.85 | L3MBTL1 (0.55) | L3MBTL1GAAPKMMAPTTP53 | |
| SCHEMBL162987 | 0.83 | TP53 (0.64) | L3MBTL1GAATP53TSHRPLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102070579-B | The preparation method of 2-normal-butyl-3-(4-replaces propoxy-benzoyl)-5-substituted-amino cumarone | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2016-03-09 | — | — | CN | claimed |
| CN-102070579-A | Method for preparing 2-n-butyl-3-(4-substituted-propoxybenzoyl)-5-substituted aminobenzofuran | SHANGHAI INST PHARM INDUSTRY | 2011-05-25 | — | — | CN | claimed |
| CN-102070579-B | The preparation method of 2-normal-butyl-3-(4-replaces propoxy-benzoyl)-5-substituted-amino cumarone | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2016-03-09 | — | — | CN | disclosed |
| CN-102070577-B | 2-normal-butyl-3-(4-replaces propoxy-benzoyl)-5-substituted-amino cumarone and application thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2016-03-09 | — | — | CN | disclosed |
| CN-102757444-B | There is the benzofuran compounds of nitric oxide donors character | NANJING XINNUOTHAI PHARMACEUTICAL CO., LTD. (CN) | 2016-02-10 | — | — | CN | disclosed |
| CN-102070581-B | The preparation of 2-normal-butyl-3-(4-(the amino propoxy-of 3-di-n-butyl) benzoyl)-5-aminobenzofur | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2015-11-25 | — | — | CN | disclosed |
| CN-102757444-A | Benzofuran compound with nitrous oxide donor property | JIANGSU SIMCERE PHARM RES CO | 2012-10-31 | — | — | CN | disclosed |
| EP-2509971-A1 | NEW PROCESS FOR THE PREPARATION OF DRONEDARONE | SANOFI (FR) | 2012-10-17 | — | — | EP | disclosed |
| CN-102741238-A | New process for the preparation of dronedarone | SANOFI AVENTIS | 2012-10-17 | — | — | CN | disclosed |
| WO-2011070380-A1 | NEW PROCESS FOR THE PREPARATION OF DRONEDARONE | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| CN-102070579-A | Method for preparing 2-n-butyl-3-(4-substituted-propoxybenzoyl)-5-substituted aminobenzofuran | SHANGHAI INST PHARM INDUSTRY | 2011-05-25 | — | — | CN | disclosed |
| CN-102070581-A | Preparation of 2-n-butyl-3-(4-(3-di-n-butylaminopropyl) benzoyl)-5-amino benzofuran | SHANGHAI INST PHARM INDUSTRY | 2011-05-25 | — | — | CN | disclosed |
| CN-102070577-A | 2-n-butyl-3-(4-subsitituted propylbenzoyl)-5-substituted amino benzofuran and application thereof | SHANGHAI INST PHARM INDUSTRY | 2011-05-25 | — | — | CN | disclosed |
| EP-1315710-B1 | AMINOALKOXYBENZOYL-BENZOFURAN OR BENZOTHIOPHENE DERIVATIVES, METHOD FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2007-04-25 | — | — | EP | disclosed |
| US-7148240-B2 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same | SANOFI-AVENTIS (FR) | 2006-12-12 | — | — | US | disclosed |
| CN-1471520-A | Aminoalkyl benzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same | ʥŵ��-�ϳ�ʵ���ҹ�˾ | 2004-01-28 | — | — | CN | disclosed |
| US-20040010011-A1 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same | SANOFI (FR) | 2004-01-15 | — | — | US | disclosed |
| EP-1315710-A1 | AMINOALKOXYBENZOYL-BENZOFURAN OR BENZOTHIOPHENE DERIVATIVES, METHOD FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2003-06-04 | — | — | EP | disclosed |
| WO-2002016340-A1 | AMINOALKOXYBENZOYL-BENZOFURAN OR BENZOTHIOPHENE DERIVATIVES, METHOD FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAME | SANOFI-SYNTHELABO (FR) | 2002-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040010011-A1 | Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same | ABAT, TNNT2, BCAT1 | L3MBTL1 4238/4885GAA 1255/4885PKM 435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.