Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | NEK2 | P51955 | 5/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.36 |
| ▸ | NTSR1 | P30989 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | DCK | P27707 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20331865 | 0.94 | PDE10A (0.37) | NEK2NTSR1 | |
| SCHEMBL21252083 | 0.90 | PDE10A (0.34) | PIK3CAMTORTTK | |
| SCHEMBL21240276 | 0.88 | NTSR1 (0.35) | PIK3CANEK2PLK1NEK1NTSR1 | |
| SCHEMBL21252058 | 0.88 | FGFR4 (0.40) | PIK3CAMTORNEK2PLK1NEK1 | |
| SCHEMBL21252340 | 0.86 | PIK3CA (0.47) | PIK3CAMTOR | |
| SCHEMBL21251916 | 0.85 | TTK (0.39) | PIK3CANEK2PLK1NEK1JAK2 | |
| SCHEMBL21251873 | 0.85 | PIK3CA (0.37) | PIK3CAMTORNEK2PLK1NEK1 | |
| SCHEMBL21251668 | 0.83 | NTSR1 (0.39) | PIK3CAMTORNTSR1MAP4K4 | |
| SCHEMBL20332232 | 0.83 | PDE10A (0.37) | NTSR1TTK | |
| SCHEMBL21252007 | 0.83 | PIK3CA (0.36) | PIK3CAMTORNEK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |