Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 4/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.33 |
| ▸ | GAK | O14976 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21240563 | 0.95 | FGFR4 (0.35) | TTKLRRK2GAKFGFR4PDE10A | |
| SCHEMBL21251716 | 0.86 | PDE10A (0.38) | FGFR4PDE10APDE3BPDE3AFGFR1 | |
| SCHEMBL21252155 | 0.86 | GAK (0.36) | TTKLRRK2GAKFGFR4PDE10A | |
| SCHEMBL21252118 | 0.84 | PRKD1 (0.37) | GAKFGFR4FGFR1FGFR2 | |
| SCHEMBL21251714 | 0.83 | FGFR4 (0.34) | FGFR4PDE10ACHRM4FGFR1FGFR2 | |
| SCHEMBL20331980 | 0.83 | TTK (0.37) | TTKLRRK2GAKCHRM4CYP1A2 | |
| SCHEMBL21251851 | 0.83 | SMN1; SMN2 (0.41) | FGFR4FGFR1FGFR2 | |
| SCHEMBL21320754 | 0.81 | TTK (0.37) | TTKFGFR4PDE10APDE3BPDE3A | |
| SCHEMBL29577769 | 0.81 | PDE10A (0.36) | TTKLRRK2GAKPDE10APDE3B | |
| SCHEMBL20331744 | 0.81 | PDE10A (0.36) | TTKLRRK2GAKPDE10APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018113584-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2018-06-28 | — | — | WO | disclosed |