Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 5/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29577707 | 0.95 | TTK (0.38) | TTKGAKLRRK2 | |
| SCHEMBL21240264 | 0.95 | TTK (0.38) | TTKGAKLRRK2 | |
| SCHEMBL24488200 | 0.92 | TTK (0.37) | TTKGAKLRRK2 | |
| SCHEMBL21251736 | 0.87 | TTK (0.35) | TTK | |
| SCHEMBL20331101 | 0.84 | MEN1 (0.36) | CHRM4 | |
| SCHEMBL20332233 | 0.83 | TTK (0.33) | TTKGAKCHRM4LRRK2CYP1A2 | |
| SCHEMBL21252449 | 0.83 | TTK (0.38) | TTKGAKLRRK2 | |
| SCHEMBL20331786 | 0.83 | TTK (0.33) | TTK | |
| SCHEMBL20331108 | 0.82 | HRH4 (0.35) | — | |
| SCHEMBL20331783 | 0.82 | F10 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018113584-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2018-06-28 | — | — | WO | disclosed |