Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.51 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20333057 | 0.93 | LMNA (0.60) | LMNAHTTATMKDM4ESMN1; SMN2 | |
| SCHEMBL20333034 | 0.86 | LMNA (0.51) | LMNAHTTATMKDM4ESMN1; SMN2 | |
| SCHEMBL20333476 | 0.81 | LMNA (0.58) | LMNAHTTATMKDM4ESMN1; SMN2 | |
| SCHEMBL20333478 | 0.79 | LMNA (0.58) | LMNAHTTATMKDM4ESMN1; SMN2 | |
| SCHEMBL876387 | 0.78 | RAB9A (0.58) | LMNAKDM4ESMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL27680029 | 0.76 | LMNA (1.00) | LMNAHTTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL20285149 | 0.76 | LMNA (0.57) | LMNAHTTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL20333479 | 0.76 | HTT (0.51) | LMNAHTTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL20333473 | 0.75 | SMN1; SMN2 (0.51) | LMNAHTTATMKDM4ESMN1; SMN2 | |
| SCHEMBL6369514 | 0.75 | KCNA5 (0.58) | LMNAHTTKDM4ESMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018117166-A1 | THIAZOLE DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT OF SAME | キッセイ薬品工業株式会社 | 2018-06-28 | — | — | WO | disclosed |