Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.60 |
| ▸ | MEN1 | O00255 | 8/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 8/20 | 0.59 |
| ▸ | RAB9A | P51151 | 8/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | CASP2 | P42575 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22216671 | 0.86 | MEN1 (0.60) | KMT2AMEN1TP53ALDH1A1NPC1 | |
| SCHEMBL22216493 | 0.86 | MEN1 (0.60) | KMT2AMEN1TP53ALDH1A1NPC1 | |
| SCHEMBL20347168 | 0.83 | MEN1 (0.56) | KMT2AMEN1TP53ALDH1A1NPC1 | |
| SCHEMBL20333771 | 0.83 | NPC1 (0.56) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL308069 | 0.79 | NPC1 (0.75) | KMT2AMEN1TP53ALDH1A1NPC1 | |
| SCHEMBL20334149 | 0.75 | RAB9A (0.49) | KMT2AMEN1TP53ALDH1A1NPC1 | |
| SCHEMBL29684837 | 0.75 | RAB9A (0.71) | KMT2AMEN1TP53ALDH1A1NPC1 | |
| SCHEMBL1685916 | 0.74 | SMN1; SMN2 (0.48) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL1929165 | 0.73 | NPC1 (0.85) | KMT2AMEN1TP53ALDH1A1NPC1 | |
| SCHEMBL8868420 | 0.72 | NPC1 (0.73) | KMT2AMEN1TP53ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119284-A1 | ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF | CALITHERA BIOSCIENCES, INC. (US) | 2018-06-28 | — | — | WO | disclosed |