Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20333380 | 0.75 | KMT2A (0.60) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL22216493 | 0.71 | MEN1 (0.60) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL20350547 | 0.70 | ALDH1A1 (0.46) | MAPTALDH1A1HSD17B10TDP1LMNA | |
| SCHEMBL29684837 | 0.70 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL308069 | 0.69 | NPC1 (0.75) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL22216671 | 0.69 | MEN1 (0.60) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL20347168 | 0.68 | MEN1 (0.56) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL22216571 | 0.66 | ALDH1A1 (0.48) | SMN1; SMN2MAPTALDH1A1HSD17B10TDP1 | |
| SCHEMBL12495837 | 0.65 | NPC1 (1.00) | RAB9ANPC1SMN1; SMN2TP53MAPT | |
| SCHEMBL28130084 | 0.64 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119284-A1 | ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF | CALITHERA BIOSCIENCES, INC. (US) | 2018-06-28 | — | — | WO | disclosed |