Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20231639 | 0.83 | MAPK1 (0.36) | MAPK1ACHESLC18A3ALDH1A1LMNA | |
| SCHEMBL19977427 | 0.83 | MAPK1 (0.36) | MAPK1ACHESLC18A3ALDH1A1LMNA | |
| SCHEMBL26804417 | 0.82 | CCR2 (0.34) | ACHEALDH1A1 | |
| SCHEMBL21341636 | 0.82 | ALDH1A1 (0.32) | MAPK1ACHEALDH1A1 | |
| SCHEMBL26029865 | 0.82 | ALDH1A1 (0.32) | MAPK1ACHEALDH1A1 | |
| SCHEMBL20234755 | 0.82 | ALDH1A1 (0.32) | MAPK1ACHEALDH1A1 | |
| SCHEMBL20314521 | 0.81 | ACHE (0.33) | ACHEALDH1A1 | |
| SCHEMBL19958993 | 0.81 | KCNH2 (0.38) | — | |
| SCHEMBL19959067 | 0.81 | KCNH2 (0.38) | — | |
| SCHEMBL19959057 | 0.81 | KCNH2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119357-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ENHANCER OF ZESTE HOMOLOG 2 POLYPEPTIDE | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |