Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20353077 | 1.00 | PRMT6 (0.39) | PRMT6ADORA1ADORA3P2RY12ADORA2A | |
| SCHEMBL29642897 | 0.96 | PRMT6 (0.37) | PRMT6ADORA1ADORA3P2RY12 | |
| SCHEMBL26533859 | 0.89 | PRMT6 (0.40) | PRMT6ADORA1ADORA3P2RY12ADORA2A | |
| SCHEMBL25496115 | 0.88 | ADK (0.34) | — | |
| SCHEMBL17325415 | 0.85 | PRMT6 (0.38) | PRMT6ADORA1ADORA3P2RY12ADORA2A | |
| SCHEMBL18496436 | 0.85 | PRMT6 (0.48) | PRMT6ADORA1ADORA3P2RY12ADORA2A | |
| SCHEMBL18048070 | 0.85 | PRMT6 (0.48) | PRMT6ADORA1ADORA3P2RY12ADORA2A | |
| SCHEMBL18992232 | 0.85 | PRMT6 (0.48) | PRMT6ADORA1ADORA3P2RY12ADORA2A | |
| SCHEMBL29558159 | 0.85 | PRMT6 (0.48) | PRMT6ADORA1ADORA3P2RY12ADORA2A | |
| SCHEMBL17860554 | 0.85 | PRMT6 (0.48) | PRMT6ADORA1ADORA3P2RY12ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11766447-B2 | 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2023-09-26 | — | — | US | disclosed |
| US-11766447-B2 | 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. (CZ) | 2023-09-26 | — | — | US | disclosed |
| US-20220160746-A1 | 3'3'-CYCLIC DINUCLEOTIDE ANALOGUE COMPRISING A CYCLOPENTANYL MODIFIED NUCLEOTIDE AS STING MODULATOR | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I (CZ) | 2022-05-26 | — | — | US | disclosed |
| EP-3935065-A1 | 3'3'-CYCLIC DINUCLEOTIDE ANALOGUE COMPRISING A CYCLOPENTANYL MODIFIED NUCLEOTIDE AS STING MODULATOR | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. (CZ) | 2022-01-12 | — | — | EP | disclosed |
| US-10450341-B2 | Cyclic di-nucleotides as modulators of STING | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-10-22 | — | — | US | disclosed |
| EP-3152217-B1 | CYCLIC DI-NUCLEOTIDES AS MODULATORS OF STING | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-08-01 | — | — | EP | disclosed |
| US-20180186828-A1 | CYCLIC DI-NUCLEOTIDES AS MODULATORS OF STING | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-07-05 | — | — | US | disclosed |
| US-20180186828-A1 | CYCLIC DI-NUCLEOTIDES AS MODULATORS OF STING | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11766447-B2 | 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator | STING1, MAVS, CGAS | PRMT6 1569/4885ADORA1 1854/4885ADORA3 1201/4885 |
| US-20220160746-A1 | 3'3'-CYCLIC DINUCLEOTIDE ANALOGUE COMPRISING A CYCLOPENTANYL MODIFIED NUCLEOTIDE AS STING MODULATOR | STING1, MAVS, CGAS | PRMT6 1645/4885ADORA1 1736/4885ADORA3 1049/4885 |
| US-10450341-B2 | Cyclic di-nucleotides as modulators of STING | STING1, CGAS, IRF3 | PRMT6 4520/4885ADORA1 119/4885ADORA3 381/4885 |
| US-20180186828-A1 | CYCLIC DI-NUCLEOTIDES AS MODULATORS OF STING | STING1, CGAS, IRF3 | PRMT6 4520/4885ADORA1 119/4885ADORA3 381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.