SCHEMBL20337698

SCHEMBL20337698

COc1ncncc1-c1nc2cc(F)c(F)cc2n1C1CC1

nearest known ligand 0.77

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 19/20 0.77
CYP11B1 P15538 18/20 0.77
CYP19A1 P11511 1/20 0.67
CYP3A4 P08684 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31411949 0.87 CYP11B2 (1.00) CYP11B2CYP11B1CYP19A1CYP3A4
SCHEMBL20337629 0.87 CYP11B2 (1.00) CYP11B2CYP11B1CYP19A1CYP3A4
SCHEMBL31411968 0.87 CYP11B2 (0.63) CYP11B2CYP11B1CYP19A1
SCHEMBL20337725 0.87 CYP11B2 (0.63) CYP11B2CYP11B1CYP19A1
SCHEMBL20337789 0.82 CYP11B2 (0.78) CYP11B2CYP11B1CYP19A1CYP3A4
SCHEMBL20337677 0.82 CYP11B1 (1.00) CYP11B2CYP11B1CYP19A1CYP3A4
SCHEMBL31411989 0.82 CYP11B2 (1.00) CYP11B2CYP11B1CYP19A1CYP3A4
SCHEMBL31411963 0.82 CYP11B2 (1.00) CYP11B2CYP11B1CYP19A1CYP3A4
SCHEMBL31411996 0.82 CYP11B1 (1.00) CYP11B2CYP11B1CYP19A1CYP3A4
SCHEMBL20337656 0.82 CYP11B2 (1.00) CYP11B2CYP11B1CYP19A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3562306-B1 METALLOENZYME INHIBITOR COMPOUNDS JI XING PHARMACEUTICALS HONG KONG LTD (HK) 2025-02-26 EP disclosed
US-11919883-B2 Metalloenzyme inhibitor compounds JI XING PHARMACEUTICALS HONG KONG LIMITED (HK) 2024-03-05 US disclosed
US-20220009907-A1 METALLOENZYME INHIBITOR COMPOUNDS CORXEL PHARMACEUTICALS HONG KONG LIMITED (HK) 2022-01-13 US disclosed
US-20220009907-A1 METALLOENZYME INHIBITOR COMPOUNDS CORXEL PHARMACEUTICALS HONG KONG LIMITED (HK) 2022-01-13 US disclosed
US-11136309-B2 Metalloenzyme inhibitor compounds PHASEBIO PHARMACEUTICALS, INC. (US) 2021-10-05 US disclosed
US-11136309-B2 Metalloenzyme inhibitor compounds PHASEBIO PHARMACEUTICALS, INC. (US) 2021-10-05 US disclosed
US-20200392112-A1 METALLOENZYME INHIBITOR COMPOUNDS CORXEL PHARMACEUTICALS HONG KONG LIMITED (HK) 2020-12-17 US disclosed
US-20200392112-A1 METALLOENZYME INHIBITOR COMPOUNDS CORXEL PHARMACEUTICALS HONG KONG LIMITED (HK) 2020-12-17 US disclosed
EP-3562306-A2 METALLOENZYME INHIBITOR COMPOUNDS Selenity Therapeutics (Bermuda), Ltd. (BM) 2019-11-06 EP disclosed
US-20180186773-A1 METALLOENZYME INHIBITOR COMPOUNDS CORXEL PHARMACEUTICALS HONG KONG LIMITED (HK) 2018-07-05 US disclosed
US-20180186773-A1 METALLOENZYME INHIBITOR COMPOUNDS CORXEL PHARMACEUTICALS HONG KONG LIMITED (HK) 2018-07-05 US disclosed
US-20180186773-A1 METALLOENZYME INHIBITOR COMPOUNDS CORXEL PHARMACEUTICALS HONG KONG LIMITED (HK) 2018-07-05 US disclosed
WO-2018125799-A2 METALLOENZYME INHIBITOR COMPOUNDS VIAMET PHARMACEUTICALS (BERMUDA), LTD. (BM) 2018-07-05 WO disclosed
WO-2018125799-A2 METALLOENZYME INHIBITOR COMPOUNDS VIAMET PHARMACEUTICALS (BERMUDA), LTD. (BM) 2018-07-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200392112-A1 METALLOENZYME INHIBITOR COMPOUNDS SOD1, RNASE1, FECH CYP11B2 405/4885CYP11B1 370/4885CYP19A1 1309/4885
US-20220009907-A1 METALLOENZYME INHIBITOR COMPOUNDS SOD1, RNASE1, FECH CYP11B2 405/4885CYP11B1 370/4885CYP19A1 1309/4885
US-20180186773-A1 METALLOENZYME INHIBITOR COMPOUNDS SOD1, RNASE1, FECH CYP11B2 405/4885CYP11B1 370/4885CYP19A1 1309/4885
US-11136309-B2 Metalloenzyme inhibitor compounds SOD1, RNASE1, FECH CYP11B2 405/4885CYP11B1 370/4885CYP19A1 1309/4885
US-11919883-B2 Metalloenzyme inhibitor compounds SOD1, RNASE1, FECH CYP11B2 405/4885CYP11B1 370/4885CYP19A1 1309/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.