Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | EIF4E | P06730 | 1/20 | 0.70 |
| ▸ | EIF4G1 | Q04637 | 1/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | STAT3 | P40763 | 1/20 | 0.68 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.64 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.62 |
| ▸ | APEX1 | P27695 | 1/20 | 0.61 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.59 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20339746 | 1.00 | MAPT (0.70) | MAPTMEN1KMT2AMCL1ALDH1A1 | |
| SCHEMBL23145046 | 0.92 | STAT3 (0.76) | MAPTMEN1KMT2AMCL1ALDH1A1 | |
| SCHEMBL18301010 | 0.92 | STAT3 (0.76) | MAPTMEN1KMT2AMCL1ALDH1A1 | |
| SCHEMBL46211 | 0.92 | STAT3 (0.76) | MAPTMEN1KMT2AMCL1ALDH1A1 | |
| SCHEMBL20339302 | 0.90 | STAT3 (0.74) | MAPTMEN1KMT2AMCL1ALDH1A1 | |
| SCHEMBL20339299 | 0.90 | STAT3 (0.74) | MAPTMEN1KMT2AMCL1ALDH1A1 | |
| SCHEMBL20339661 | 0.90 | STAT3 (0.70) | MAPTMEN1KMT2AMCL1ALDH1A1 | |
| SCHEMBL20339659 | 0.90 | STAT3 (0.70) | MAPTMEN1KMT2AMCL1ALDH1A1 | |
| SCHEMBL20339627 | 0.89 | MEN1 (0.71) | MAPTMEN1KMT2AMCL1ALDH1A1 | |
| SCHEMBL20339629 | 0.89 | MEN1 (0.71) | MAPTMEN1KMT2AMCL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200123146-A1 | HETEROCYCLIC INTEGRIN AGONISTS | GB006 INC (US) | 2020-04-23 | — | — | US | disclosed |
| US-20200123146-A1 | HETEROCYCLIC INTEGRIN AGONISTS | GB006 INC (US) | 2020-04-23 | — | — | US | disclosed |
| WO-2018126072-A1 | HETEROCYCLIC INTEGRIN AGONISTS | ADHAERE PHARMACEUTICALS, INC. (US) | 2018-07-05 | — | — | WO | disclosed |
| WO-2018126072-A1 | HETEROCYCLIC INTEGRIN AGONISTS | ADHAERE PHARMACEUTICALS, INC. (US) | 2018-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123146-A1 | HETEROCYCLIC INTEGRIN AGONISTS | ITGA1, ITGA4, ITGA2 | MAPT 4821/4885MEN1 3711/4885KMT2A 2000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.