Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetophenazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 6/20 | 0.89 |
| ▸ | HRH1 | P35367 | 8/20 | 0.89 |
| ▸ | HTR1A | P08908 | 6/20 | 0.89 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.89 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.89 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.89 |
| ▸ | DRD3 | P35462 | 6/20 | 0.89 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.89 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.89 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.89 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.89 |
| ▸ | HTR2A | P28223 | 5/20 | 0.89 |
| ▸ | HTR2B | P41595 | 5/20 | 0.89 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.89 |
| ▸ | DRD1 | P21728 | 4/20 | 0.89 |
| ▸ | MLNR | O43193 | 1/20 | 0.89 |
| ▸ | ESR1 | P03372 | 1/20 | 0.89 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.89 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.89 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetophenazine SCHEMBL29710923 | 0.94 | HRH1 (1.00) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Acetophenazine SCHEMBL94266 | 0.94 | HRH1 (1.00) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Acetophenazine SCHEMBL27848793 | 0.89 | HRH1 (0.89) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Acetophenazine SCHEMBL123792 | 0.89 | HRH1 (0.89) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Acetophenazine SCHEMBL30903895 | 0.89 | HRH1 (0.89) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Acetophenazine SCHEMBL123789 | 0.89 | HRH1 (0.89) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Acetophenazine SCHEMBL1155759 | 0.89 | HRH1 (0.89) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| SCHEMBL141601 | 0.87 | HTR1A (0.86) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Acetophenazine SCHEMBL123791 | 0.87 | HRH1 (0.85) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Perphenazine SCHEMBL8014634 | 0.84 | MAPT (0.88) | HRH1HTR1ADRD2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11052055-B2 | Modular transdermal delivery system and associated methods of manufacture and use | PURE RATIOS HOLDING, INC (US) | 2021-07-06 | — | — | US | disclosed |
| US-20200268681-A1 | MODULAR TRANSDERMAL DELIVERY SYSTEM AND ASSOCIATED METHODS OF MANUFACTURE AND USE | International Bioceutical Co. LLC (US) | 2020-08-27 | — | — | US | disclosed |
| US-20200146998-A1 | MODULAR TRANSDERMAL DELIVERY SYSTEM AND ASSOCIATED METHODS OF MANUFACTURE AND USE | International Bioceutical Co. LLC (US) | 2020-05-14 | — | — | US | disclosed |
| US-20180311181-A1 | Modular Transdermal Delivery Systems for the Treatment of Insomnia and Anxiety | International Bioceutical Co. LLC (US) | 2018-11-01 | — | — | US | disclosed |
| US-20180311180-A1 | Modular Transdermal Delivery Systems for the Treatment of Pain and Inflammation | International Bioceutical Co. LLC (US) | 2018-11-01 | — | — | US | disclosed |
| US-20180296498-A1 | MODULAR TRANSDERMAL DELIVERY SYSTEM AND ASSOCIATED METHODS OF MANUFACTURE AND USE | International Bioceutical Co. LLC (US) | 2018-10-18 | — | — | US | disclosed |
| WO-2018126225-A1 | MODULAR TRANSDERMAL DELIVERY SYSTEM AND ASSOCIATED METHODS OF MANUFACTURE AND USE | INTERNATIONAL BIOCEUTICAL COMPANY, LLC (US) | 2018-07-05 | — | — | WO | disclosed |