Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetophenazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 6/20 | 0.89 |
| ▸ | HRH1 | P35367 | 9/20 | 0.89 |
| ▸ | HTR1A | P08908 | 6/20 | 0.89 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.89 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.89 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.89 |
| ▸ | DRD3 | P35462 | 6/20 | 0.89 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.89 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.89 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.89 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.89 |
| ▸ | HTR2A | P28223 | 5/20 | 0.89 |
| ▸ | HTR2B | P41595 | 5/20 | 0.89 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.89 |
| ▸ | DRD1 | P21728 | 4/20 | 0.89 |
| ▸ | MLNR | O43193 | 1/20 | 0.89 |
| ▸ | ESR1 | P03372 | 1/20 | 0.89 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.89 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.89 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetophenazine SCHEMBL123789 | 1.00 | HRH1 (0.89) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Acetophenazine SCHEMBL1155759 | 1.00 | HRH1 (0.89) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Acetophenazine SCHEMBL30903895 | 1.00 | HRH1 (0.89) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Acetophenazine SCHEMBL94266 | 0.94 | HRH1 (1.00) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Acetophenazine SCHEMBL29710923 | 0.94 | HRH1 (1.00) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Fluphenazine SCHEMBL7623667 | 0.92 | LMNA (0.74) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Acetophenazine SCHEMBL123791 | 0.91 | HRH1 (0.85) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Carphenazine SCHEMBL120590 | 0.91 | HRH1 (0.72) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Acetophenazine SCHEMBL2448563 | 0.89 | LMNA (0.71) | HRH1HTR1ADRD2SLC6A2SLC6A4 | |
| Acetophenazine SCHEMBL20339946 | 0.89 | HRH1 (0.89) | HRH1HTR1ADRD2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2066 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230003721-A1 | MITOTHERAPEUTICS FOR THE TREATMENT OF BRAIN DISORDERS | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2023-01-05 | — | — | US | claimed |
| US-20200095627-A1 | MOLECULAR SENSORS AND USES THEREOF | NEW YORK UNIVERSITY | 2020-03-26 | — | — | US | claimed |
| US-20190145960-A1 | COMPOSITIONS, SYSTEMS AND METHODS FOR GENE EXPRESSION NOISE DRUG SCREENING AND USES THEREOF | THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE | 2019-05-16 | — | — | US | claimed |
| EP-3470536-A1 | COMPOSITIONS, SYSTEMS AND METHODS FOR GENE EXPRESSION NOISE DRUG SCREENING AND USES THEREOF | The J. David Gladstone Institutes (US) | 2019-04-17 | — | — | EP | claimed |
| US-10184933-B2 | Compositions, systems and methods for gene expression noise drug screening and uses thereof | The J. David Gladstone Industries (US) | 2019-01-22 | — | — | US | claimed |
| US-20170112829-A1 | USE OF COMPOUNDS BINDING TO THE SIGMA RECEPTOR LIGANDS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2017-04-27 | — | — | US | claimed |
| US-20160245796-A1 | COMPOSITIONS, SYSTEMS AND METHODS FOR GENE EXPRESSION NOISE DRUG SCREENING AND USES THEREOF | THE J. DAVID GLADSTONE INSTITUTES (US) | 2016-08-25 | — | — | US | claimed |
| EP-3052662-A1 | COMPOSITIONS, SYSTEMS AND METHODS FOR GENE EXPRESSION NOISE DRUG SCREENING AND USES THEREOF | The J. David Gladstone Institutes (US) | 2016-08-10 | — | — | EP | claimed |
| EP-1349835-B1 | (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE, COMPOSITIONS AND USES THEREOF | EUTHYMICS BIOSCIENCE INC (US) | 2016-03-30 | — | — | EP | claimed |
| US-20150148256-A1 | BIOLUMINESCENCE IMAGING-BASED SCREENING ASSAY AND INHIBITORS OF ABCG2 | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-05-28 | — | — | US | claimed |
| WO-2002066427-A2 | (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE, COMPOSITIONS AND USES THEREOF | DOV PHARMACEUTICAL, INC. (US) | 2002-08-29 | — | — | WO | claimed |
| US-6372919-B1 | SUBSTANTIALLY FREE OF CORRESPONDING (-)-ENANTIOMER | DOV PHARMACEUTICAL, INC. | 2002-04-16 | — | — | US | claimed |
| US-6197764-B1 | COMPLEX WITH FATTY ACID; THERAPY FOR PSYCHOLOGICAL DISORDERS | PROTARGA, INC. | 2001-03-06 | — | — | US | claimed |
| EP-1044023-A1 | A COVALENT CONJUGATE OF CLOZAPINE WITH A FATTY ACID AND ITS USE FOR TREATING SCHIZOPHRENIA | Protarga Inc. (US) | 2000-10-18 | — | — | EP | claimed |
| US-5955459-A | Fatty acid-antipsychotic compositions and uses thereof | NEUROMEDICA, INC. (US) | 1999-09-21 | — | — | US | claimed |
| WO-1999026661-A1 | A COVALENT CONJUGATE OF CLOZAPINE WITH A FATTY ACID AND ITS USE FOR TREATING SCHIZOPHRENIA | PROTARGA INC. (US) | 1999-06-03 | — | — | WO | claimed |
| EP-0580776-A1 | USE OF SIGMA RECEPTOR ANTAGONISTS TO ENHANCE THE EFFECTS OF ANTIPSYCHOTIC DRUGS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-02-02 | — | — | EP | claimed |
| WO-1992018127-A1 | USE OF SIGMA RECEPTOR ANTAGONISTS TO ENHANCE THE EFFECTS OF ANTIPSYCHOTIC DRUGS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-10-29 | — | — | WO | claimed |
| EP-0180364-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING PHENOTHIAZINES | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1990-03-07 | — | — | EP | claimed |
| EP-0180364-A2 | Pharmaceutical compositions containing phenothiazines | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1986-05-07 | — | — | EP | claimed |