Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 4/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27258483 | 0.81 | HSD11B1 (0.41) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL20343499 | 0.75 | HSD11B1 (0.47) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL20343378 | 0.75 | HSD11B1 (0.47) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL4436959 | 0.74 | ALDH1A1 (0.52) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL4446700 | 0.74 | ALDH1A1 (0.52) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL20343582 | 0.74 | HSD11B1 (0.45) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL20343593 | 0.74 | CHRNB2 (0.62) | HSD11B1EPHX2CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL30334337 | 0.73 | DPP4 (0.44) | EPHX2JAK1JAK3JAK2TYK2 | |
| SCHEMBL1982249 | 0.73 | CHRNB2 (0.58) | CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL20343512 | 0.73 | JAK2 (0.41) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2796460-B1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2018-07-04 | — | — | EP | disclosed |