SCHEMBL20344752

SCHEMBL20344752

CCCn1c(=O)ccc2cc(NS(=O)(=O)Cc3ccc(C)cc3F)ccc21

nearest known ligand 0.50

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
BRPF1 P55201 11/20 0.50
HDAC8 Q9BY41 4/20 0.40
BRD1 O95696 4/20 0.38
BRD4 O60885 3/20 0.38
BRD9 Q9H8M2 2/20 0.38
BRPF3 Q9ULD4 2/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
ECE1 P42892 1/20 0.36
NR1I2 O75469 1/20 0.36
PTGDR2 Q9Y5Y4 3/20 0.34
MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20344757 0.86 BRPF1 (0.50) BRPF1HDAC8BRD1BRD4BRD9
SCHEMBL20616475 0.85 BRPF1 (0.38) BRPF1HDAC8BRD4HDAC1HDAC6
SCHEMBL20616477 0.84 BRPF1 (0.55) BRPF1HDAC8BRD1BRD4BRD9
SCHEMBL20344727 0.84 BRPF1 (0.52) BRPF1HDAC8BRD1BRD4BRD9
SCHEMBL22756346 0.83 BRPF1 (0.54) BRPF1HDAC8BRD1BRD4BRD9
SCHEMBL20344777 0.82 BRPF1 (0.50) BRPF1HDAC8BRD1BRD4BRD9
SCHEMBL20344753 0.79 BRPF1 (0.35) BRPF1PTGDR2MAPT
SCHEMBL20344719 0.78 BRPF1 (0.47) BRPF1HDAC8BRD1BRD4BRD9
SCHEMBL17979387 0.75 MAPT (0.45) BRPF1MAPT
SCHEMBL20344748 0.73 BRD4 (0.41) HDAC8BRD4HDAC1HDAC6MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3342766-B1 SMALL MOLECULE COMPOUND FOR ENHANCING PLANT STRESS RESISTANCE CAS CENTER FOR EXCELLENCE IN MOLECULAR PLANT SCIENCES (CN) 2020-12-09 EP disclosed
US-10842151-B2 Small molecule compound for enhancing plant stress resistance CAS CENTER FOR EXCELLENCE IN MOLECULAR PLANT SCIENCES (CN) 2020-11-24 US disclosed
EP-3342766-A1 SMALL MOLECULE COMPOUND FOR ENHANCING PLANT STRESS RESISTANCE Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (CN) 2018-07-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10842151-B2 Small molecule compound for enhancing plant stress resistance CYP4F11, RICTOR, MYB BRPF1 1596/4885HDAC8 2101/4885BRD1 1074/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.